Tuberculosis diagnostics: overcoming ancient challenges with modern solutions

M MacGregor-Fairlie, S Wilkinson… - Emerging topics in …, 2020 - portlandpress.com
Rapid, sensitive, accurate and portable diagnostics are a mainstay of modern medicine.
Tuberculosis is a disease that has been with us since time immemorial and, despite the fact …

Bacteriologically confirmed extrapulmonary tuberculosis and the associated risk factors among extrapulmonary tuberculosis suspected patients in Ethiopia: A …

G Diriba, A Alemu, K Eshetu, B Yenew, DF Gamtesa… - PLoS …, 2022 - journals.plos.org
Background The actual burden of bacteriologically confirmed extrapulmonary tuberculosis
(EPTB) and risk factors in Ethiopia is not well known due to the lack of a strong surveillance …

[HTML][HTML] STAT1 and CXCL10 involve in M1 macrophage polarization that may affect osteolysis and bone remodeling in extrapulmonary tuberculosis

T Liang, J Chen, GY Xu, Z Zhang, J Xue, H Zeng… - Gene, 2022 - Elsevier
Objective This study was aimed to reveal the molecular mechanism of bone destruction due
to macrophage polarization leading to during extrapulmonary tuberculosis (EPTB) infection …

[HTML][HTML] Extrapulmonary tuberculosis among migrants in Europe, 1995 to 2017

SE Hayward, K Rustage, LB Nellums… - Clinical Microbiology …, 2021 - Elsevier
Objectives The proportion of tuberculosis (TB) cases occurring in migrants in Europe is
increasing. Extrapulmonary TB poses challenges in diagnosis and treatment and causes …

Bridging the gap between policy and practice: a qualitative analysis of providers' field experiences tinkering with directly observed therapy in patients with drug …

KM Mussie, C Gradmann, T Manyazewal - BMJ open, 2020 - bmjopen.bmj.com
Objectives Drug-resistant tuberculosis (DR-TB) is one of the major public health threats in
low-income countries such as Ethiopia. It is intertwined with larger socioeconomic and …

[HTML][HTML] Ferroptosis-related gene SOCS1, a marker for tuberculosis diagnosis and treatment, involves in macrophage polarization and facilitates bone destruction in …

T Liang, J Chen, GY Xu, Z Zhang, J Xue, H Zeng… - Tuberculosis, 2022 - Elsevier
This study was aimed to reveal the role of ferroptosis in tuberculosis infection. To elucidate
the ferroptosis-related DEGs, GEO datasets associated with tuberculosis infection were …

[HTML][HTML] Tracing TB: are there predictors for active TB disease in patients with Xpert Ultra trace results?

WB Dowling, A Whitelaw, P Nel - International Journal of Infectious …, 2022 - Elsevier
Abstract Objectives The Xpert MTB/Rif Ultra (Xpert Ultra; Cepheid, USA) has increased
sensitivity compared with its predecessor (Gene Xpert), due to the addition of multicopy …

[HTML][HTML] Incidence and determinants of tuberculosis among HIV-positive individuals in Addis Ababa, Ethiopia: A retrospective cohort study

A Alemu, A Yesuf, B Zerihun, M Getu, T Worku… - International Journal of …, 2020 - Elsevier
Objective To assess the incidence and determinants of tuberculosis (TB) among HIV-
positive individuals in selected health facilities of Addis Ababa, Ethiopia, during the period …

Incidence and predictors of extrapulmonary tuberculosis among people living with Human Immunodeficiency Virus in Addis Ababa, Ethiopia: A retrospective cohort …

A Alemu, A Yesuf, E Gebrehanna, B Zerihun, M Getu… - PloS one, 2020 - journals.plos.org
Background Extrapulmonary tuberculosis is an emerging public health problem among HIV
positives compared to the general population. This study aimed to assess the incidence and …

Utility of line probe assay in detecting drug resistance and the associated mutations in patients with extrapulmonary tuberculosis in Addis Ababa, Ethiopia

G Diriba, A Kebede, HH Tola, A Alemu… - SAGE Open …, 2022 - journals.sagepub.com
Introduction: Molecular tests allow rapid detection of Mycobacterium tuberculosis and drug
resistance in a few days. Identifying the mutations in genes associated with drug resistance …