[HTML][HTML] Reciprocal regulation of mesenchymal stem cells and immune responses
Mesenchymal stem/stromal cells (MSCs) exist in almost all tissues and participate in tissue
regeneration and homeostasis. In-vitro-expanded MSCs are employed as therapeutics for …
regeneration and homeostasis. In-vitro-expanded MSCs are employed as therapeutics for …
Emerging phagocytosis checkpoints in cancer immunotherapy
Cancer immunotherapy, mainly including immune checkpoints-targeted therapy and the
adoptive transfer of engineered immune cells, has revolutionized the oncology landscape as …
adoptive transfer of engineered immune cells, has revolutionized the oncology landscape as …
Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer
Colorectal cancer (CRC) is among the most common malignancies with limited treatments
other than surgery. The tumor microenvironment (TME) profiling enables the discovery of …
other than surgery. The tumor microenvironment (TME) profiling enables the discovery of …
Mesenchymal stromal/stem cell (MSC)-derived exosomes in clinical trials
A Lotfy, NM AboQuella, H Wang - Stem Cell Research & Therapy, 2023 - Springer
Mesenchymal stromal/stem cells (MSCs) are widely utilized in cell therapy because of their
robust immunomodulatory and regenerative properties. Their paracrine activity is one of the …
robust immunomodulatory and regenerative properties. Their paracrine activity is one of the …
[HTML][HTML] Mesenchymal stromal cells: putative microenvironmental modulators become cell therapy
M Krampera, K Le Blanc - Cell stem cell, 2021 - cell.com
An exceptional safety profile has been shown in a large number of cell therapy clinical trials
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …
A brief overview of global trends in MSC-based cell therapy
Human mesenchymal stem cells (MSCs), also known as mesenchymal stromal cells or
medicinal signaling cells, are important adult stem cells for regenerative medicine, largely …
medicinal signaling cells, are important adult stem cells for regenerative medicine, largely …
[HTML][HTML] Transplantation of ACE2-mesenchymal stem cells improves the outcome of patients with COVID-19 pneumonia
Z Leng, R Zhu, W Hou, Y Feng, Y Yang, Q Han… - Aging and …, 2020 - ncbi.nlm.nih.gov
Abstract A coronavirus (HCoV-19) has caused the novel coronavirus disease (COVID-19)
outbreak in Wuhan, China. Preventing and reversing the cytokine storm may be the key to …
outbreak in Wuhan, China. Preventing and reversing the cytokine storm may be the key to …
Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and …
Clinical evidence indicates that the fatal outcome observed with severe acute respiratory
syndrome-coronavirus-2 infection often results from alveolar injury that impedes airway …
syndrome-coronavirus-2 infection often results from alveolar injury that impedes airway …
Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19: a phase 1 clinical trial
F Meng, R Xu, S Wang, Z Xu, C Zhang, Y Li… - Signal transduction and …, 2020 - nature.com
No effective drug treatments are available for coronavirus disease 2019 (COVID-19). Host-
directed therapies targeting the underlying aberrant immune responses leading to …
directed therapies targeting the underlying aberrant immune responses leading to …
Mesenchymal stromal cell apoptosis is required for their therapeutic function
Multipotent mesenchymal stromal cells (MSCs) ameliorate a wide range of diseases in
preclinical models, but the lack of clarity around their mechanisms of action has impeded …
preclinical models, but the lack of clarity around their mechanisms of action has impeded …