Reciprocal regulation of mesenchymal stem cells and immune responses
Mesenchymal stem/stromal cells (MSCs) exist in almost all tissues and participate in tissue
regeneration and homeostasis. In-vitro-expanded MSCs are employed as therapeutics for …
regeneration and homeostasis. In-vitro-expanded MSCs are employed as therapeutics for …
Shattering barriers toward clinically meaningful MSC therapies
More than 1050 clinical trials are registered at FDA. gov that explore multipotent
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …
Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer
Colorectal cancer (CRC) is among the most common malignancies with limited treatments
other than surgery. The tumor microenvironment (TME) profiling enables the discovery of …
other than surgery. The tumor microenvironment (TME) profiling enables the discovery of …
[PDF][PDF] Mesenchymal stromal cells: putative microenvironmental modulators become cell therapy
M Krampera, K Le Blanc - Cell stem cell, 2021 - cell.com
An exceptional safety profile has been shown in a large number of cell therapy clinical trials
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …
[HTML][HTML] Transplantation of ACE2-mesenchymal stem cells improves the outcome of patients with COVID-19 pneumonia
Z Leng, R Zhu, W Hou, Y Feng, Y Yang, Q Han… - Aging and …, 2020 - ncbi.nlm.nih.gov
Abstract A coronavirus (HCoV-19) has caused the novel coronavirus disease (COVID-19)
outbreak in Wuhan, China. Preventing and reversing the cytokine storm may be the key to …
outbreak in Wuhan, China. Preventing and reversing the cytokine storm may be the key to …
Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and …
Clinical evidence indicates that the fatal outcome observed with severe acute respiratory
syndrome-coronavirus-2 infection often results from alveolar injury that impedes airway …
syndrome-coronavirus-2 infection often results from alveolar injury that impedes airway …
Mesenchymal stromal cell apoptosis is required for their therapeutic function
Multipotent mesenchymal stromal cells (MSCs) ameliorate a wide range of diseases in
preclinical models, but the lack of clarity around their mechanisms of action has impeded …
preclinical models, but the lack of clarity around their mechanisms of action has impeded …
Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19: a phase 1 clinical trial
F Meng, R Xu, S Wang, Z Xu, C Zhang, Y Li… - Signal transduction and …, 2020 - nature.com
No effective drug treatments are available for coronavirus disease 2019 (COVID-19). Host-
directed therapies targeting the underlying aberrant immune responses leading to …
directed therapies targeting the underlying aberrant immune responses leading to …
Current status of potential therapeutic candidates for the COVID-19 crisis
J Zhang, B Xie, K Hashimoto - Brain, behavior, and immunity, 2020 - Elsevier
Abstract As of April 15, 2020, the ongoing coronavirus disease 2019 (COVID-2019)
pandemic has swept through 213 countries and infected more than 1,870,000 individuals …
pandemic has swept through 213 countries and infected more than 1,870,000 individuals …
Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients: a randomized, double-blind, placebo-controlled phase …
L Shi, H Huang, X Lu, X Yan, X Jiang, R Xu… - Signal transduction and …, 2021 - nature.com
Abstract Treatment of severe Coronavirus Disease 2019 (COVID-19) is challenging. We
performed a phase 2 trial to assess the efficacy and safety of human umbilical cord …
performed a phase 2 trial to assess the efficacy and safety of human umbilical cord …