Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

SM Man, R Karki, TD Kanneganti - Immunological reviews, 2017 - Wiley Online Library
Cell death is a fundamental biological phenomenon that is essential for the survival and
development of an organism. Emerging evidence also indicates that cell death contributes to …

Cutaneous leishmaniasis: immune responses in protection and pathogenesis

P Scott, FO Novais - Nature Reviews Immunology, 2016 - nature.com
Cutaneous leishmaniasis is a major public health problem and causes a range of diseases
from self-healing infections to chronic disfiguring disease. Currently, there is no vaccine for …

Immune responses in leishmaniasis: an overview

AC Costa-da-Silva, DO Nascimento… - Tropical medicine and …, 2022 - mdpi.com
Leishmaniasis is a parasitic, widespread, and neglected disease that affects more than 90
countries in the world. More than 20 Leishmania species cause different forms of …

How to master the host immune system? Leishmania parasites have the solutions!

M Rossi, N Fasel - International immunology, 2018 - academic.oup.com
Infection by protozoan parasites of the genus Leishmania results in the development of
leishmaniasis, an increasingly prevalent group of diseases affecting over 12 million people …

Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis

A Ardain, R Domingo-Gonzalez, S Das, SW Kazer… - Nature, 2019 - nature.com
Tuberculosis is the leading cause of death by an infectious disease worldwide. However, the
involvement of innate lymphoid cells (ILCs) in immune responses to infection with …

Pro-and anti-inflammatory cytokines in cutaneous leishmaniasis: a review

N Maspi, A Abdoli, F Ghaffarifar - Pathogens and global health, 2016 - Taylor & Francis
Cutaneous leishmaniasis (CL) is caused by different species of the genus Leishmania. Pro-
and anti-inflammatory cytokines play different roles in resistance/susceptibility and the …

Cytosolic recognition of microbes and pathogens: inflammasomes in action

JA Hayward, A Mathur, C Ngo… - … and Molecular Biology …, 2018 - Am Soc Microbiol
Infection is a dynamic biological process underpinned by a complex interplay between the
pathogen and the host. Microbes from all domains of life, including bacteria, viruses, fungi …

Clash of the Cytokine Titans: counter-regulation of interleukin-1 and type I interferon-mediated inflammatory responses

KD Mayer-Barber, B Yan - Cellular & molecular immunology, 2017 - nature.com
Over the past decades the notion of 'inflammation'has been extended beyond the original
hallmarks of rubor (redness), calor (heat), tumor (swelling) and dolor (pain) described by …

Gut microbes egested during bites of infected sand flies augment severity of leishmaniasis via inflammasome-derived IL-1β

R Dey, AB Joshi, F Oliveira, L Pereira… - Cell host & …, 2018 - cell.com
Leishmania donovani parasites are the cause of visceral leishmaniasis and are transmitted
by bites from phlebotomine sand flies. A prominent feature of vector-transmitted Leishmania …

[HTML][HTML] Macrophages as host, effector and immunoregulatory cells in leishmaniasis: Impact of tissue micro-environment and metabolism

C Bogdan - Cytokine: X, 2020 - Elsevier
Leishmania are protozoan parasites that predominantly reside in myeloid cells within their
mammalian hosts. Monocytes and macrophages play a central role in the pathogenesis of …