Glioblastoma multiforme (GBM) is an aggressive brain tumor with high mortality rates. Due to
its invasiveness, heterogeneity, and incomplete resection, the treatment is very challenging …

The chemistry and short lifetimes of metal‐based anti‐cancer drugs can be turned into an
advantage for direct injections into tumors, which then allow the use of highly cytotoxic …

Glioma is the most common tumor of the central nervous system (CNS), with a 5-year
survival rate of< 35%. Drug therapy, such as chemotherapeutic and immunotherapeutic …

A paradigm shift in treating the most aggressive and malignant form of glioma is
continuously evolving; however, these strategies do not provide a better life and survival …

Abnormal levels of autophagy have been implicated in the pathogenesis of multiple
diseases, including cancer. However, little is known about the role of autophagy-related …

Pressure-induced infusion of solutions into brain tissue is used both in research and in
medicine. In medicine, convection enhanced delivery (CED) may be used to deliver agents …

Glioblastoma (GBM) is the most common and aggressive primary brain cancer;
angiogenesis and immunosuppression exacerbate GBM progression. COUP-TFII …

A novel suicide gene therapy approach was tested in U87 MG glioblastoma multiforme cells.
A 26nt G-rich double-stranded DNA aptamer (AS1411) was integrated into a vector at the …

Abstract microRNAs (miRNAs) have been found to affect various cancers, and expression of
numerous miRNAs is revealed in glioma. However, the role of microRNA-30b-3p (miR-30b …

The purpose of this study was to design a polyamidoamine (PAMAM)-based nanovector for
the efficient delivery of methotrexate to U87 glioma cells. To this end, 0–100% acetylated …