Behaviours of complex biomolecular systems are often irreducible to the elementary
properties of their individual components. Explanatory and predictive mathematical models …

Genomic information on tumors from 50 cancer types cataloged by the International Cancer
Genome Consortium (ICGC) shows that only a few well-studied driver genes are frequently …

Computation underlies the organization of cells into higher-order structures, for example
during development or the spatial association of bacteria in a biofilm,,. Each cell performs a …

Mathematical modeling of biological processes provides deep insights into complex cellular
systems. While quantitative and continuous models such as differential equations have been …

Modular and orthogonal genetic logic gates are essential for building robust biologically
based digital devices to customize cell signalling in synthetic biology. Here we constructed …

The logical (or logic) formalism is increasingly used to model regulatory and signaling
networks. Complementing these applications, several groups contributed various methods …

The discovery of potent inhibitors of the BRAF proto-oncogene has revolutionized therapy
for melanoma harboring mutations in BRAF, yet NRAS-mutant melanoma remains without …

Cellular signal transduction is a complex process involving protein-protein interactions
(PPIs) that transmit information. For example, signals from the plasma membrane may be …

Identifying control strategies for biological networks is paramount for practical applications
that involve reprogramming a cell's fate, such as disease therapeutics and stem cell …

Background Cells process signals using complex and dynamic networks. Studying how this
is performed in a context and cell type specific way is essential to understand signaling both …