Regulatory networks defining EMT during cancer initiation and progression
Epithelial to mesenchymal transition (EMT) is essential for driving plasticity during
development, but is an unintentional behaviour of cells during cancer progression. The EMT …
development, but is an unintentional behaviour of cells during cancer progression. The EMT …
Epigenetics of Alzheimer's disease
There are currently no validated biomarkers which can be used to accurately diagnose
Alzheimer's disease (AD) or to distinguish it from other dementia-causing neuropathologies …
Alzheimer's disease (AD) or to distinguish it from other dementia-causing neuropathologies …
MicroRNA control of bone formation and homeostasis
JB Lian, GS Stein, AJ Van Wijnen, JL Stein… - Nature Reviews …, 2012 - nature.com
MicroRNAs (miRNAs) repress cellular protein levels to provide a sophisticated parameter of
gene regulation that coordinates a broad spectrum of biological processes. Bone …
gene regulation that coordinates a broad spectrum of biological processes. Bone …
Knowledge about the presence or absence of miRNA isoforms (isomiRs) can successfully discriminate amongst 32 TCGA cancer types
AG Telonis, R Magee, P Loher… - Nucleic acids …, 2017 - academic.oup.com
Isoforms of human miRNAs (isomiRs) are constitutively expressed with tissue-and disease-
subtype-dependencies. We studied 10 271 tumor datasets from The Cancer Genome Atlas …
subtype-dependencies. We studied 10 271 tumor datasets from The Cancer Genome Atlas …
microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus
Abstract microRNAs regulate the expression of over 60% of protein coding genes by
targeting their mRNAs to AGO2-containing complexes in the cytoplasm and promoting their …
targeting their mRNAs to AGO2-containing complexes in the cytoplasm and promoting their …
Dysregulation of microRNAs in breast cancer and their potential role as prognostic and predictive biomarkers in patient management
E van Schooneveld, H Wildiers, I Vergote… - Breast cancer …, 2015 - Springer
MicroRNAs (miRNAs) are an emerging class of gene expression modulators with relevant
roles in several biological processes, including cell differentiation, development, apoptosis …
roles in several biological processes, including cell differentiation, development, apoptosis …
[HTML][HTML] MicroRNAs shape the neuronal landscape
E McNeill, D Van Vactor - Neuron, 2012 - cell.com
The nervous system equips us with capability to adapt to many conditions and
circumstances. We rely on an armamentarium of intricately formed neural circuits for many of …
circumstances. We rely on an armamentarium of intricately formed neural circuits for many of …
Regulation of microRNAs in cancer metastasis
Metastasis is a phenomenon of crucial importance in defining prognosis in patients with
cancer and is often responsible for cancer-related mortality. It is known that several steps are …
cancer and is often responsible for cancer-related mortality. It is known that several steps are …
miR-9 modulates the expression of interferon-regulated genes and MHC class I molecules in human nasopharyngeal carcinoma cells
The functions of miR-9 in some cancers are recently implicated in regulating proliferation,
epithelial–mesenchymal transition (EMT), invasion and metastasis, apoptosis, and tumor …
epithelial–mesenchymal transition (EMT), invasion and metastasis, apoptosis, and tumor …
Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations
Transactive response DNA-binding protein 43 (TDP-43) is a major pathological protein in
frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). There are many …
frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). There are many …