The clinical problem of symptomatic Alzheimer disease and mild cognitive impairment

R Tarawneh, DM Holtzman - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Alzheimer disease (AD) is the most common cause of dementia in the elderly.
Clinicopathological studies support the presence of a long preclinical phase of the disease …

Distinguishing Alzheimer's disease from other major forms of dementia

S Karantzoulis, JE Galvin - Expert review of neurotherapeutics, 2011 - Taylor & Francis
Alzheimer's disease (AD) is the most common and most studied cause of dementia.
Significant advances have been made since the first set of clinical criteria for AD were put …

A network dysfunction perspective on neurodegenerative diseases

JJ Palop, J Chin, L Mucke - Nature, 2006 - nature.com
Patients with Alzheimer's disease or other neurodegenerative disorders show remarkable
fluctuations in neurological functions, even during the same day. These fluctuations cannot …

What best differentiates Lewy body from Alzheimer's disease in early-stage dementia?

P Tiraboschi, DP Salmon, LA Hansen, RC Hofstetter… - Brain, 2006 - academic.oup.com
To determine which clinical feature (s)[among visual hallucinations (VH), extrapyramidal
signs (EPS) and visuospatial impairment] in the earliest stages of disease best predicted a …

Electrophysiological changes precede morphological changes to frontal cortical pyramidal neurons in the rTg4510 mouse model of progressive tauopathy

JL Crimins, AB Rocher, JI Luebke - Acta neuropathologica, 2012 - Springer
Whole-cell patch-clamp recordings and high-resolution morphometry were used to assess
functional and structural properties of layer 3 pyramidal neurons in early (< 4 months) and …

[图书][B] Clinical diagnosis and management of Alzheimer's disease

S Gauthier - 2006 - books.google.com
The third edition of this successful textbook has been completely updated throughout and
includes new chapters on electrophysiological tests, biological markers, global staging …

[HTML][HTML] Improving the clinical detection of Lewy body dementia with the Lewy body composite risk score

JE Galvin - Alzheimer's & dementia: diagnosis, assessment & …, 2015 - Elsevier
Abstract Introduction Dementia with Lewy bodies (DLB) is a challenge to diagnose,
particularly outside of expert centers with long delays in diagnosis leading to significant …

[HTML][HTML] Improving the identification of dementia with Lewy bodies in the context of an Alzheimer's-type dementia

AJ Thomas, F Mahin-Babaei, M Saidi, D Lett… - Alzheimer's research & …, 2018 - Springer
Abstract Background Dementia due to Alzheimer's disease (AD) and dementia with Lewy
bodies (DLB) are the two most common neurodegenerative causes of dementia. They …

Association between male gender and cortical Lewy body pathology in large autopsy series

PT Nelson, FA Schmitt, GA Jicha, RJ Kryscio… - Journal of …, 2010 - Springer
Sex-linked factors may alter risk for neurodegenerative diseases. Definitive diagnoses are
not established until autopsy, so neuropathological studies are critical. There have not been …

11C-DTBZ and 18F-FDG PET measures in differentiating dementias

RA Koeppe, S Gilman, A Joshi, S Liu… - Journal of Nuclear …, 2005 - Soc Nuclear Med
Accurate, early differentiation of dementias will become increasingly important as new
therapies are introduced. Differential diagnosis by standard clinical criteria has limited …