Structurally dynamic hydrogels for biomedical applications: pursuing a fine balance between macroscopic stability and microscopic dynamics

K Zhang, Q Feng, Z Fang, L Gu, L Bian - Chemical Reviews, 2021 - ACS Publications
Owing to their unique chemical and physical properties, hydrogels are attracting increasing
attention in both basic and translational biomedical studies. Although the classical hydrogels …

Functional and biomimetic materials for engineering of the three-dimensional cell microenvironment

G Huang, F Li, X Zhao, Y Ma, Y Li, M Lin, G Jin… - Chemical …, 2017 - ACS Publications
The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

[PDF][PDF] Vascular tissue engineering: progress, challenges, and clinical promise

HHG Song, RT Rumma, CK Ozaki, ER Edelman… - Cell stem cell, 2018 - cell.com
Although the clinical demand for bioengineered blood vessels continues to rise, current
options for vascular conduits remain limited. The synergistic combination of emerging …

Biomaterials and emerging anticancer therapeutics: engineering the microenvironment

L Gu, DJ Mooney - Nature Reviews Cancer, 2016 - nature.com
The microenvironment is increasingly recognized to have key roles in cancer, and
biomaterials provide a means to engineer microenvironments both in vitro and in vivo to …

[HTML][HTML] Microfluidic modelling of the tumor microenvironment for anti-cancer drug development

M Shang, RH Soon, CT Lim, BL Khoo, J Han - Lab on a Chip, 2019 - pubs.rsc.org
Cancer is the leading cause of death worldwide. The complex and disorganized tumor
microenvironment makes it very difficult to treat this disease. The most common in vitro drug …

A review of hydrogel-based composites for biomedical applications: enhancement of hydrogel properties by addition of rigid inorganic fillers

S Utech, AR Boccaccini - Journal of materials science, 2016 - Springer
There is a growing demand for three-dimensional scaffolds for expanding applications in
regenerative medicine, tissue engineering, and cell culture techniques. The material …

Printing technologies for medical applications

A Shafiee, A Atala - Trends in molecular medicine, 2016 - cell.com
Over the past 15 years, printers have been increasingly utilized for biomedical applications
in various areas of medicine and tissue engineering. This review discusses the current and …

Biopolymers for antitumor implantable drug delivery systems: recent advances and future outlook

S Talebian, J Foroughi, SJ Wade, KL Vine… - Advanced …, 2018 - Wiley Online Library
In spite of remarkable improvements in cancer treatments and survivorship, cancer still
remains as one of the major causes of death worldwide. Although current standards of care …

Bioprinting the cancer microenvironment

YS Zhang, M Duchamp, R Oklu… - ACS biomaterials …, 2016 - ACS Publications
Cancer is intrinsically complex, comprising both heterogeneous cellular compositions and
microenvironmental cues. During the various stages of cancer initiation, development, and …

3D liver tissue model with branched vascular networks by multimaterial bioprinting

X Liu, X Wang, L Zhang, L Sun, H Wang… - Advanced …, 2021 - Wiley Online Library
Complicated vessels pervade almost all body tissues and influence the pathophysiology of
the human body significantly. However, current fabrication strategies have limited success at …