Numerous epidemiologic time-series studies have shown generally consistent associations
of cardiovascular hospital admissions and mortality with outdoor air pollution, particularly …

Serine hydrolases (SHs) consist of> 200 enzymes in humans characterized by the presence
of an active site serine that is used for the hydrolysis of substrates. The membership of this …

Endothelin (ET) peptides and their receptors are intimately involved in the physiological
control of systemic blood pressure and body Na homeostasis, exerting these effects through …

Dysfunction of the vascular endothelium is a hallmark of most conditions that are associated
with atherosclerosis and is therefore held to be an early feature in atherogenesis. However …

An enormous number of studies in the last two decades have been devoted to investigating
the role of the endothelium in cardiovascular diseases. Nonetheless, the optimal …

The kidney plays a fundamental role in maintaining body salt and fluid balance and blood
pressure homeostasis through the actions of its proximal and distal tubular segments of …

Blood flow (BF) increases with increasing exercise intensity in skeletal, respiratory, and
cardiac muscle. In humans during maximal exercise intensities, 85% to 90% of total cardiac …

Globally, stroke is a leading cause of death and long-term disability. Over the past decades,
several efforts have attempted to discover new drugs or repurpose existing therapeutics to …

Abstract Endothelin-1 (ET-1) is involved in the regulation of a myriad of processes highly
relevant for physical and mental well-being; female and male health; in the modulation of …

Background Diets rich in inorganic nitrate are associated with lower blood pressure, an
effect that may be mediated by an improvement of endothelial function (EF). Therefore, a …