18F-labeled positron emission tomographic radiopharmaceuticals in oncology: an overview of radiochemistry and mechanisms of tumor localization

S Vallabhajosula - Seminars in nuclear medicine, 2007 - Elsevier
Molecular imaging is the visualization, characterization, and measurement of biological
processes at the molecular and cellular levels in a living system. At present, positron …

Effect of obesity on breast cancer development

MP Cleary, ME Grossmann, A Ray - Veterinary pathology, 2010 - journals.sagepub.com
In recent years, obesity has been identified as a risk factor for the development of breast
cancer in postmenopausal women, and it has been associated with a poor outcome. Many …

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

T Sørlie, CM Perou, R Tibshirani… - Proceedings of the …, 2001 - National Acad Sciences
The purpose of this study was to classify breast carcinomas based on variations in gene
expression patterns derived from cDNA microarrays and to correlate tumor characteristics to …

Metabolic flare: indicator of hormone responsiveness in advanced breast cancer

JE Mortimer, F Dehdashti, BA Siegel… - Journal of Clinical …, 2001 - ascopubs.org
PURPOSE: The purpose of this study was to investigate whether positron emission
tomography (PET) with the glucose analog [18F] fluorodeoxyglucose (FDG) and the …

A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer

W Xia, S Bacus, P Hegde, I Husain… - Proceedings of the …, 2006 - National Acad Sciences
The development of acquired resistance to ErbB2 tyrosine kinase inhibitors limits the clinical
efficacy of this class of cancer therapeutics. Little is known about the mechanism (s) of …

[PDF][PDF] Positron tomographic assessment of estrogen receptors in breast cancer: comparison with FDG-PET and in vitro receptor assays

F Dehdashti, JE Mortimer, BA Siegel… - Journal of Nuclear …, 1995 - Soc Nuclear Med
16a-[18F] fluoro-1713-estradiol (FES) and [18Fjfluoro-2-deoxy-D-glucose (FDG) to validate
the concordance between tumor es trogen-receptor (ER) status as determined by FES-PET …

Survival in patients with brain metastases from breast cancer: the importance of HER‐2 status

AF Eichler, I Kuter, P Ryan, L Schapira… - … Journal of the …, 2008 - Wiley Online Library
BACKGROUND Brain metastases (BM) are the most common intracranial tumors in adults.
To the authors' knowledge, established prognostic factors for survival after the diagnosis of …

Resistance to tamoxifen‐induced apoptosis is associated with direct interaction between Her2/neu and cell membrane estrogen receptor in breast cancer

YL Chung, ML Sheu, SC Yang, CH Lin… - International journal of …, 2002 - Wiley Online Library
Overexpression of Her2/neu is implicated in the development of resistance to the
antiestrogen tamoxifen (TAM) that exerts its inhibitory effect through interaction with estrogen …

ER, PR, HER2, Ki-67 and CK5 in early and late relapsing breast cancer—Reduced CK5 expression in metastases

K Joensuu, M Leidenius, M Kero… - Breast cancer: basic …, 2013 - journals.sagepub.com
Breast cancer can recur even decades after the primary therapy. Markers are needed to
predict cancer progression and the risk of late recurrence. The estrogen receptor (ER) …

Oestrogen receptor (ESR) polymorphisms and breast cancer susceptibility

TI Anderson, KR Heimdal, M Skrede, K Tveit, K Berg… - Human Genetics, 1994 - Springer
The allele frequencies of three restriction fragment length polymorphisms at the oestrogen
receptor (ESR) locus were compared between breast cancer patients and controls …