The neuroimmune axis of Alzheimer's disease

M Jorfi, A Maaser-Hecker, RE Tanzi - Genome Medicine, 2023 - Springer
Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder with
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …

Multiple sclerosis: Neuroimmune crosstalk and therapeutic targeting

M Charabati, MA Wheeler, HL Weiner, FJ Quintana - Cell, 2023 - cell.com
Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central
nervous system afflicting nearly three million individuals worldwide. Neuroimmune …

[PDF][PDF] Bifidobacteria-mediated immune system imprinting early in life

BM Henrick, L Rodriguez, T Lakshmikanth, C Pou… - Cell, 2021 - cell.com
Immune-microbe interactions early in life influence the risk of allergies, asthma, and other
inflammatory diseases. Breastfeeding guides healthier immune-microbe relationships by …

The role of TH17 cells in multiple sclerosis: Therapeutic implications

T Moser, K Akgün, U Proschmann, J Sellner… - Autoimmunity …, 2020 - Elsevier
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) where immunopathology is thought to be mediated by myelin-reactive CD4+ T …

[HTML][HTML] Critical role of interleukin (IL)-17 in inflammatory and immune disorders: An updated review of the evidence focusing in controversies

JMGR de Morales, L Puig, E Daudén, JD Cañete… - Autoimmunity …, 2020 - Elsevier
Abstract Interleukin 17 (IL-17) is a proinflammatory cytokine that has been the focus of
intensive research because of its crucial role in the pathogenesis of different diseases …

Interleukin-17 in chronic inflammatory neurological diseases

J Milovanovic, A Arsenijevic, B Stojanovic… - Frontiers in …, 2020 - frontiersin.org
A critical role for IL-17, a cytokine produced by T helper 17 (Th17) cells, has been indicated
in the pathogenesis of chronic inflammatory and autoimmune diseases. A positive effect of …

IL-17 in chronic inflammation: from discovery to targeting

A Beringer, M Noack, P Miossec - Trends in molecular medicine, 2016 - cell.com
Interleukin-17 (IL-17) is a cytokine which elicits protection against extracellular bacterial and
fungal infections and which plays important roles in inflammation. However, when produced …

Effector T cells in multiple sclerosis

BJ Kaskow, C Baecher-Allan - Cold Spring …, 2018 - perspectivesinmedicine.cshlp.org
Multiple sclerosis (MS) has long been considered a CD4 T-cell disease, primarily because
of the findings that the strongest genetic risk for MS is the major histocompatibility complex …

Regulation of immune function by vitamin D and its use in diseases of immunity

AS Vanherwegen, C Gysemans… - … and Metabolism Clinics, 2017 - endo.theclinics.com
The immune system, innate and adaptive, is a highly evolved and complex network,
essential for promoting survival in an environment full of potential pathogens, while …

T helper cells: the modulators of inflammation in multiple sclerosis

M Kunkl, S Frascolla, C Amormino, E Volpe, L Tuosto - Cells, 2020 - mdpi.com
Multiple sclerosis (MS) is a chronic neurodegenerative disease characterized by the
progressive loss of axonal myelin in several areas of the central nervous system (CNS) that …