5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

The last decade has witnessed a tremendous progress in the acute therapy of migraine, with
sumatriptan, belonging to a new class of drugs, now known as 5-HT1B/1D/1F receptor …

Migraine headache pathophysiology involves trigeminovascular system activation,
calcitonin gene-related peptide (CGRP) release, and dysfunctional nociceptive …

This study assessed the possible antinociceptive role of peripheral 5-HT1 receptor subtypes
in the rat formalin test. Rats were injected into the dorsum of the hind paw with 50 μl of …

In this review, first a historical perspective of serotonin's (5-HT) involvement in female sexual
behavior is presented. Then an overview of studies implicating 5-HT is presented. The effect …

Introduction: The introduction of the triptans (5-hydroxytryptamine (5-HT) 1B/1D receptor
agonists) was a great improvement in the acute treatment of migraine. However …

We have previously shown that 5-HT 1B receptors inhibit prejunctionally the rat
vasodepressor CGRPergic sensory outflow. Since 5-HT 1 receptors comprise 5-HT 1A, 5-HT …

Continuous infusions of 5‐hydroxytryptamine (5‐HT) inhibit the tachycardiac responses to
preganglionic (C7‐T1) sympathetic stimulation in pithed rats pretreated with desipramine …

Several morphological works have shown that the globus pallidus (GP) contains the highest
density of 5-HT1B receptors within the telencephalon. However, the role of these receptors …

Background Dihydroergotamine (DHE) is an antimigraine drug that produces cranial
vasoconstriction and inhibits trigeminal CGRP release; furthermore, it inhibits the …