Circadian disruption is pervasive and can occur at multiple organizational levels,
contributing to poor health outcomes at individual and population levels. Evidence points to …

Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

Abstract Alzheimer's disease (AD), the most common cause of dementia, results in a
sustained decline in cognition. There are currently few effective disease modifying therapies …

As we age, we experience changes in our nighttime sleep and daytime wakefulness.
Individuals afflicted with Alzheimer's disease (AD) can develop sleep problems even before …

Background: The Religious Orders Study and Rush Memory and Aging Project are both
ongoing longitudinal clinical-pathologic cohort studies of aging and Alzheimer's disease …

In mammals, a central circadian clock, located in the suprachiasmatic nuclei (SCN) of the
hypothalamus, tunes the innate circadian physiological rhythms to the ambient 24 h light …

Introduction Precision medicine methodologies and approaches have advanced our
understanding of the clinical presentation, development, progression, and management of …

Older adults do not sleep as well as younger adults. Why? What alterations in sleep quantity
and quality occur as we age, and are there functional consequences? What are the …

Nearly half of all adults older than 60 years of age report sleep disturbance, as characterised
either by reports of insomnia complaints with daytime consequences, dissatisfaction with …

To evaluate the quality of available evidence on the effects of environmental noise exposure
on sleep a systematic review was conducted. The databases PSYCINFO, PubMed, Science …