Risk of developing Alzheimer's disease is increased by older age, genetic factors, and
several medical risk factors. Studies have also suggested that dietary and lifestyle factors …

Targeting the amyloid‐β (Aβ) peptide cascade has been at the heart of therapeutic
developments in Alzheimer's disease (AD) research for more than 25 years, yet no …

Although sleep appears to be broadly conserved in animals, the physiological functions of
sleep remain unclear. In this study, we sought to identify a physiological defect common to a …

Introduction Daytime napping is frequently seen in older adults. The longitudinal relationship
between daytime napping and cognitive aging is unknown. Methods Using data from 1401 …

Movement-based sleep-wake detection devices (ie, actigraphy devices) were first
developed in the early 1970s and have repeatedly been validated against …

Importance The apolipoprotein E (APOE [GenBank, 348; OMIM, 107741]) ε4 allele is a
common and well-established genetic risk factor for Alzheimer disease (AD). Sleep …

Approximately half of older people report sleep disturbances, which are associated with
various health conditions, including neurodegenerative disease and dementia. Indeed, 60 to …

Nighttime restlessness and daytime drowsiness are common and early symptoms of
Alzheimer's Disease (AD). This symptomology implicates dysfunctional biological timing, yet …

Multiple studies have examined associations between sleep and cognition in older adults,
but a majority of these depend on self-reports on sleep and utilize cognitive tests that assess …

Objective: To examine the relationship between sleep quality and cortical and hippocampal
volume and atrophy within a community-based sample, explore the influence of age on …