Objective To examine the associations of physical activity, Alzheimer disease (AD), and
other brain pathologies and cognition in older adults. Methods We studied 454 brain …

An emerging link between circadian clock function and neurodegeneration has indicated a
critical role for the molecular clock in brain health. We previously reported that deletion of the …

Ovarian hormones, including 17β-estradiol, are implicated in numerous physiological
processes, including sleep. Beginning at puberty, girls report more sleep complaints than …

Abstract Study Objectives To investigate the cumulative effect of five consecutive nights of
partial sleep deprivation (PSD) on a panel of cerebrospinal fluid (CSF) biomarkers in healthy …

This article is largely based on the recommendations of the AARP's Global Council on Brain
Health (GCBH) and aims to provide an overview of evidence from current literature and …

# 1 NEW YORK TIMES BESTSELLER• OVER ONE MILLION COPIES SOLD• A
groundbreaking manifesto on living better and longer that challenges the conventional …

Disturbance of the circadian system, manifested as disrupted daily rhythms of physiologic
parameters such as sleep, activity, and hormone secretion, has long been observed as a …

Classical laboratory strains show limited genetic diversity and do not harness natural
genetic variation. Mouse models relevant to Alzheimer's disease (AD) have largely been …

Dysfunction of circadian and sleep rhythms is an early feature of many neurodegenerative
diseases. Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in …

Late-onset Alzheimer's disease (AD) is a complex age-related neurodegenerative disorder
that likely involves epigenetic factors. To better understand the epigenetic state associated …