The Role of N6-methyladenosine Modification in Gametogenesis and Embryogenesis: Impact on Fertility

Y Wang, C Yang, H Sun, H Jiang… - Genomics …, 2024 - academic.oup.com
The most common epigenetic modification of messenger ribonucleic acids (mRNAs) is N 6-
methyladenosine (m6A), which is mainly located near the 3'untranslated region of mRNAs …

A review on the role of RNA methylation in aging-related diseases

H Wei, Y Xu, L Lin, Y Li, X Zhu - International Journal of Biological …, 2024 - Elsevier
Senescence is the underlying mechanism of organism aging and is robustly regulated at the
post-transcriptional level. This regulation involves the chemical modifications, of which the …

Identification of a New m6A Regulator‐Related Methylation Signature for Predicting the Prognosis and Immune Microenvironment of Patients with Pancreatic Cancer

T Zou, D Shi, W Wang, G Chen, X Zhang… - Mediators of …, 2023 - Wiley Online Library
Pancreatic cancer (PC) is a malignant tumor of the digestive system that has a bad
prognosis. N6‐methyladenosine (m6A) is involved in a wide variety of biological activities …

Characterization of sexual maturity-associated N6-methyladenosine in boar testes

P Zhang, F Zhang, H Sui, X Yang, Y Ji, S Zheng, W Li… - BMC genomics, 2024 - Springer
Background The health and size of the testes are crucial for boar fertility. Testicular
development is tightly regulated by epigenetics. N6-methyladenosine (m6A) modification is …

N6-methyladenosine regulator-mediated methylation modification patterns and immune infiltration characterization in Polycystic Ovary Syndrome (PCOS)

S Zhou, R Hua, S Quan - Journal of Ovarian Research, 2023 - Springer
Background Polycystic ovary syndrome (PCOS) is a multisystem-related disease whose
pathophysiology is still unclear. Several regulators of N6-methyladenosine (m6A) …

METTL14 mediates nerve growth factor-stimulated testosterone synthesis in porcine theca cells

Y Luo, Y Zhao, B Zhang, T Chen, X Chen… - Biology of …, 2024 - academic.oup.com
Ovarian theca cells produce testosterone, which acts as a vital precursor substance for
synthesizing estrogens during follicular development. Nerve growth factor (NGF) has been …

[HTML][HTML] METTL3 mediates m6A modification of hsa_circ_0072380 to regulate the progression of gestational diabetes mellitus

S Zhang, S Cai, L Ye, L Shen, C Zhu, J Huang, Z Wang… - Gene, 2024 - Elsevier
Background m6A modification plays a vital role in gestational diabetes mellitus (GDM)
progression. However, the role of METTL3 and differential m6A-modified circRNAs in GDM …

18S ribosomal RNA methyltransferase METTL5-mediated CDX2 translation regulates porcine early embryo development1

T XU, M ZHANG, Q LIU, W Xin, P LUO, LIU Tong… - Journal of Integrative …, 2023 - Elsevier
Abstract N6-methyladenosine (m6A) plays a key role in mammalian early embryonic
development and cell lineage differentiation. However, the role and mechanisms of 18S …

High Temperature–Induced m6A Epigenetic Changes Affect Early Porcine Embryonic Developmental Competence in Pigs

MH Sun, WJ Jiang, XH Li, SH Lee, G Heo… - Microscopy and …, 2023 - academic.oup.com
Abstract N6-methyladenosine (m6A), the most prevalent modification in eukaryotic
messenger RNA (mRNA), plays a key role in various developmental processes in mammals …

[PDF][PDF] Bioinformatics study and experimental validation of METTL3 regulation of immune-related genes affecting placental vascular development

J Zhao, Z Du, L Yang, J Hou, Z Zhang, Q Song, Y Wu… - 2023 - scholar.archive.org
The proper development of the placental vascular system is a crucial factor in ensuring fetal
health. m6A modi cation is a key pathophysiological mechanism in placental vascular …