Frontotemporal lobar degeneration (FTLD) is one of the most common causes of early-onset
dementia and presents with early social–emotional–behavioural and/or language changes …

Abnormal intracellular protein aggregates comprise a key characteristic in most
neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and …

Background Frontotemporal dementia is a heterogenous neurodegenerative disorder, with
about a third of cases being genetic. Most of this genetic component is accounted for by …

The discovery that heterozygous and homozygous mutations in the gene encoding
progranulin are causally linked to frontotemporal dementia and lysosomal storage disease …

Frontotemporal dementia (FTD) is the second most common young-onset dementia and is
clinically characterised by progressive behavioural change, executive dysfunction and …

Abnormal aggregates of the synaptic protein, α-synuclein, are the dominant pathology in
syndromes known as the synucleinopathies. The cellular aggregation of the protein occurs …

Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia manifested by
vivid, often frightening dreams associated with simple or complex motor behavior during …

Frontotemporal lobar degeneration (FTLD) is the umbrella term encompassing a
heterogeneous group of pathological disorders. With recent discoveries, the FTLDs have …

A major recent discovery was the identification of an expansion of a non-coding GGGGCC
hexanucleotide repeat in the C9ORF72 gene in patients with frontotemporal dementia and …

Relating clinical symptoms to neuroanatomical profiles of brain damage and ultimately to
tissue pathology is a key challenge in the field of neurodegenerative disease and …