Neuroimaging has played an important role in the characterization of the frontotemporal
dementia (FTD) syndromes, demonstrating neurodegenerative signatures that can aid in the …

Frontotemporal dementia is a clinically and pathologically heterogeneous group of
neurodegenerative disorders, with progressive impairment of behavior and language. They …

Progranulin is a highly conserved secreted protein that is expressed in multiple cell types,
both in the CNS and in peripheral tissues. Both directly and via its conversion to granulins …

Alzheimer disease (AD) and frontotemporal dementia (FTD) are two frequent forms of
primary neurodegenerative dementias with overlapping clinical symptoms. Pathogenic …

Granulin (GRN) mutations have been identified in familial frontotemporal lobar degeneration
patients with ubiquitin pathology. GRN transcript haploinsufficiency is proposed as a …

Comorbid proteinopathies are observed in many neurodegenerative disorders including
Alzheimer's disease (AD), increase with age, and influence clinical outcomes, yet the …

Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia manifested by
vivid, often frightening dreams associated with simple or complex motor behavior during …

Background Frontotemporal lobar degeneration (FTLD) is a progressive neurodegenerative
disorder that can be triggered through genetic or sporadic mechanisms. MicroRNAs …

Objectives The clinical heterogeneity of frontotemporal dementia (FTD) complicates
identification of biomarkers for clinical trials that may be sensitive during the prediagnostic …

In 2006, mutations in the granulin gene were identified in patients with familial
Frontotemporal Lobar Degeneration. Granulin transcript haploinsufficiency has been …