Biokinetics in repeated-dosing in vitro drug toxicity studies
NI Kramer, E Di Consiglio, BJ Blaauboer, E Testai - Toxicology in vitro, 2015 - Elsevier
The aim of the EU FP7 Predict-IV project was to improve the predictivity of in vitro assays for
unwanted effects of drugs after repeated dosing. The project assessed the added benefit of …
unwanted effects of drugs after repeated dosing. The project assessed the added benefit of …
In vitro Models for Chemical Toxicity: Review of their Applications and Prospects
KT Rim - Toxicology and Environmental Health Sciences, 2019 - Springer
Since it has been considered acceptable to expose animal to conditions and procedures
that would not be considered acceptable for human, animals have long been used as …
that would not be considered acceptable for human, animals have long been used as …
Modelling human variability in toxicokinetic and toxicodynamic processes using Bayesian meta‐analysis, physiologically‐based modelling and in vitro systems
E Testai, C Bechaux, FM Buratti… - EFSA Supporting …, 2021 - Wiley Online Library
This external scientific report summarises the results from thearticle 36 grant
GA/EFSA/SCER/2015/01 ″Modelling human variability in toxicokinetic and toxicodynamic …
GA/EFSA/SCER/2015/01 ″Modelling human variability in toxicokinetic and toxicodynamic …
[HTML][HTML] Integrating biokinetics and in vitro studies to evaluate developmental neurotoxicity induced by chlorpyrifos in human iPSC-derived neural stem cells …
E Di Consiglio, F Pistollato, E Mendoza-De Gyves… - Reproductive …, 2020 - Elsevier
For some complex toxicological endpoints, chemical safety assessment has conventionally
relied on animal testing. Apart from the ethical issues, also scientific considerations have …
relied on animal testing. Apart from the ethical issues, also scientific considerations have …
[HTML][HTML] Integrating distribution kinetics and toxicodynamics to assess repeat dose neurotoxicity in vitro using human BrainSpheres: a case study on amiodarone
For ethical, economical, and scientific reasons, animal experimentation, used to evaluate the
potential neurotoxicity of chemicals before their release in the market, needs to be replaced …
potential neurotoxicity of chemicals before their release in the market, needs to be replaced …
[HTML][HTML] Amiodarone-induced retinal neuronal cell apoptosis attenuated by IGF-1 via counter regulation of the PI3k/Akt/FoxO3a pathway
Amiodarone (AM) is the most effective antiarrhythmic agent currently available. However,
clinical application of AM is limited by its serious toxic adverse effects including optic …
clinical application of AM is limited by its serious toxic adverse effects including optic …
[HTML][HTML] Prediction of the dose range for adverse neurological effects of amiodarone in patients from an in vitro toxicity test by in vitro–in vivo extrapolation
Amiodarone is an antiarrhythmic agent inducing adverse effects on the nervous system,
among others. We applied physiologically based pharmacokinetic (PBPK) modeling …
among others. We applied physiologically based pharmacokinetic (PBPK) modeling …
Insulin‐like growth factor‐1 activates PI3K/Akt signalling to protect human retinal pigment epithelial cells from amiodarone‐induced oxidative injury
R Liao, F Yan, Z Zeng, H Wang, K Qiu… - British Journal of …, 2018 - Wiley Online Library
Background and Purpose Amiodarone is one of the most effective anti‐arrhythmic drugs
available, but its clinical applications are limited by toxic side effects including optic toxicity …
available, but its clinical applications are limited by toxic side effects including optic toxicity …
[HTML][HTML] In Vitro–In Vivo Extrapolation by Physiologically Based Kinetic Modeling: Experience With Three Case Studies and Lessons Learned
EA Algharably, E Di Consiglio, E Testai… - Frontiers in …, 2022 - frontiersin.org
Physiologically based kinetic (PBK) modeling has been increasingly used since the
beginning of the 21st century to support dose selection to be used in preclinical and clinical …
beginning of the 21st century to support dose selection to be used in preclinical and clinical …
[HTML][HTML] The importance of protein binding for the in vitro–in vivo extrapolation (IVIVE)—example of ibuprofen, a highly protein-bound substance
A physiologically based human kinetic model (PBHKM) was used to predict the in vivo
ibuprofen dose leading to the same concentration–time profile as measured in cultured …
ibuprofen dose leading to the same concentration–time profile as measured in cultured …