A large variety of drugs have been reported to cause peripheral neuropathies as dose-
limiting adverse effects; however, most of them primarily affect axons and/or neuronal cell …

Abstract Reaction of 3-aryl-1-(benzofuran-2-yl)-2-propen-1-ones 3a–c with malononitrile in
the presence of sufficient amount of sodium alkoxide in the corresponding alcohol proceeds …

As toxicologists and risk assessors move away from animal testing and more toward using in
vitro models and biological modeling, it is necessary to produce tools to quantify the …

The objectives of this work were the classification of dynamic metabolic biomarker
candidates and the modeling and characterization of kinetic regulatory mechanisms in …

Abstract Within the Predict-IV FP7 project a strategy for measurement of in vitro biokinetics
was developed, requiring the characterization of the cellular model used, especially …

Amiodarone (AMD), an orally potent antidysrhythmic medication that has caused hepato-
renal toxicity on long-term administration, is commonly used across the world. Zizyphus …

Amiodarone therapy is widely prescribed in patients with atrial fibrillation. The higher
prevalence of this arrhythmic heart disease, and the specific age-related issues of …

In this study, we aimed to investigate the protective effect of Vitamin U (Vit U) on amiodarone
(AMD)-induced hepatotoxicity. Male Sprague-Dawley rats were randomly divided into four …

Objetivos La amiodarona puede causar neurotoxicidad que afecte a los desenlaces de los
pacientes si se usa durante la reanimación cardiopulmonar (RCP), si bien este fármaco se …

This chapter focuses on three-dimensional (3D) models prepared from human stem-or
neural precursor cells, and on aggregating rat brain cell cultures. Patches of …