The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …

Organelles compartmentalize eukaryotic cells, enhancing their ability to respond to
environmental and developmental changes. One way in which organelles communicate and …

Lipids are a fundamental class of organic molecules implicated in a wide range of biological
processes related to their structural diversity, and based on this can be broadly classified …

Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …

Objects in all dimensions are subject to translational dynamism and dynamic mutual
interactions, and the ability to exert control over these events is one of the keys to the …

Microglial cells are the resident macrophages in the central nervous system. These cells of
mesodermal/mesenchymal origin migrate into all regions of the central nervous system …

Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet
of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Neutrophils rely predominantly on glycolytic metabolism for their biological functions,
including reactive oxygen species (ROS) production. Although pyruvate kinase M2 (PKM2) …