The role of endocrine disruptors (EDs) in the human prostate gland is an overlooked issue
even though the prostate is essential for male fertility. From experimental models, it is known …

Simple Summary Biochemical inhibition of male sex hormone function (androgen signaling),
also known as androgen deprivation therapy (ADT), for human prostate cancer remains a …

Androgen receptor (AR) is an effective therapeutic target for the treatment of prostate cancer.
We report herein the design, synthesis, and biological evaluation of highly effective …

Resistance to drugs targeting the androgen receptor (AR) signaling axis remains an
important challenge in the treatment of prostate cancer patients. Activation of alternative …

Prostate cancer (PCa) is characterised by androgen dependency. Unfortunately, under anti-
androgen treatment pressure, castration-resistant prostate cancer (CRPC) emerges …

Prostate cancer (PCa) represents the most commonly non-cutaneous diagnosed cancer in
men worldwide and occupies a very wide area of preclinical and clinical research. Targeted …

Prostatic neuroendocrine malignancies represent a spectrum of diseases. Treatment-
induced neuroendocrine differentiation (tiNED) in hormonally treated adenocarcinoma has …

El cáncer de próstata es una de las neoplasias malignas más frecuentes en la población
masculina mundial, y la enfermedad metastásica la principal causa de muerte asociada a …

Background Neuroendocrine malignancies of the prostate represent a spectrum of diseases.
Treatment-induced neuroendocrine differentiation (tiNED) in hormonally treated …

MEN1 mutations predispose patients to multiple endocrine neoplasia type 1 (MEN1), a
genetic syndrome associated with the predominant co-occurrence of endocrine tumors …