Mechanisms of microtubule organization in differentiated animal cells
A Akhmanova, LC Kapitein - Nature Reviews Molecular Cell Biology, 2022 - nature.com
Microtubules are polarized cytoskeletal filaments that serve as tracks for intracellular
transport and form a scaffold that positions organelles and other cellular components and …
transport and form a scaffold that positions organelles and other cellular components and …
The tubulin code and its role in controlling microtubule properties and functions
C Janke, MM Magiera - Nature Reviews Molecular Cell Biology, 2020 - nature.com
Microtubules are core components of the eukaryotic cytoskeleton with essential roles in cell
division, shaping, motility and intracellular transport. Despite their functional heterogeneity …
division, shaping, motility and intracellular transport. Despite their functional heterogeneity …
[HTML][HTML] Inhibition of fatty acid oxidation enables heart regeneration in adult mice
X Li, F Wu, S Günther, M Looso, C Kuenne, T Zhang… - Nature, 2023 - nature.com
Postnatal maturation of cardiomyocytes is characterized by a metabolic switch from
glycolysis to fatty acid oxidation, chromatin reconfiguration and exit from the cell cycle …
glycolysis to fatty acid oxidation, chromatin reconfiguration and exit from the cell cycle …
[HTML][HTML] The tubulin code in microtubule dynamics and information encoding
A Roll-Mecak - Developmental cell, 2020 - cell.com
Microtubules are non-covalent mesoscale polymers central to the eukaryotic cytoskeleton.
Microtubule structure, dynamics, and mechanics are modulated by a cell's choice of tubulin …
Microtubule structure, dynamics, and mechanics are modulated by a cell's choice of tubulin …
[HTML][HTML] The cytoskeleton—a complex interacting meshwork
T Hohmann, F Dehghani - Cells, 2019 - mdpi.com
The cytoskeleton of animal cells is one of the most complicated and functionally versatile
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …
[HTML][HTML] The tubulin code, from molecules to health and disease
ED McKenna, SL Sarbanes… - Annual Review of …, 2023 - annualreviews.org
Microtubules are essential dynamic polymers composed of α/β-tubulin heterodimers. They
support intracellular trafficking, cell division, cellular motility, and other essential cellular …
support intracellular trafficking, cell division, cellular motility, and other essential cellular …
Microtubules acquire resistance from mechanical breakage through intralumenal acetylation
Eukaryotic cells rely on long-lived microtubules for intracellular transport and as
compression-bearing elements. We considered that long-lived microtubules are acetylated …
compression-bearing elements. We considered that long-lived microtubules are acetylated …
The microtubule cytoskeleton in cardiac mechanics and heart failure
MA Caporizzo, BL Prosser - Nature Reviews Cardiology, 2022 - nature.com
The microtubule network of cardiac muscle cells has unique architectural and biophysical
features to accommodate the demands of the working heart. Advances in live-cell imaging …
features to accommodate the demands of the working heart. Advances in live-cell imaging …
[HTML][HTML] Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell-cycle arrest
Whether cell forces or extracellular matrix (ECM) can impact genome integrity is largely
unclear. Here, acute perturbations (∼ 1 h) to actomyosin stress or ECM elasticity cause …
unclear. Here, acute perturbations (∼ 1 h) to actomyosin stress or ECM elasticity cause …
[HTML][HTML] Technological advances in super-resolution microscopy to study cellular processes
C Bond, AN Santiago-Ruiz, Q Tang, M Lakadamyali - Molecular Cell, 2022 - cell.com
Since its initial demonstration in 2000, far-field super-resolution light microscopy has
undergone tremendous technological developments. In parallel, these developments have …
undergone tremendous technological developments. In parallel, these developments have …