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In space, cells sustain strong modifications of their mechanical environment.
Mechanosensitive molecules at the cell membrane regulate mechanotransduction pathways …

Tubulin post-translational modifications (PTMs) alter microtubule properties by affecting the
binding of microtubule-associated proteins (MAPs). Microtubule detyrosination, which …

Cancer cell migration through and away from tumors is driven in part by migration along
aligned extracellular matrix, a process known as contact guidance (CG). To concurrently …

Background Microtubules (MT) buckle and bear load during myocyte contraction, a behavior
enhanced by post-translational detyrosination. This buckling suggests a spring-like …

Background Amyloid plaques and neurofibrillary tangles, the molecular lesions that
characterize Alzheimer's disease (AD) and other forms of dementia, are emerging as …

We use optical tweezers microrheology and fluorescence microscopy to characterize the
nonlinear mesoscale mechanics and mobility of in vitro co-entangled actin-microtubule …

Microtubules are cytoskeletal polymers that separate chromosomes during mitosis and
serve as rails for intracellular transport and organelle positioning. Manipulation of …

Rationale: Impaired myocardial relaxation is an intractable feature of several heart failure
(HF) causes. In human HF, detyrosinated microtubules stiffen cardiomyocytes and impair …

Tissues of multicellular organisms are characterised by several types of specialised cell–cell
junctions. In vertebrate epithelia and endothelia, tight and adherens junctions (AJ) play …