Asthma is a chronic inflammatory airway disease resulting in airflow obstruction, which in
part can become irreversible to conventional therapies, defining the concept of airway …

Asthma treatment goals currently focus on symptom and exacerbation control rather than
remission. Remission is not identical to cure, but is a step closer. This review considers the …

Interleukin-5 (IL-5) exerts a central pathogenic role in differentiation, recruitment, survival,
and degranulation of eosinophils. Indeed, during the last years, significant advances have …

With novel therapies in development, there is an opportunity to consider asthma remission
as a treatment goal. In this Rostrum, we present a generalized framework for clinical and …

Monoclonal antibody therapies have significantly improved treatment outcomes for patients
with severe asthma; however, a significant disease burden remains. Available biologic …

Asthma is the the most common chronic respiratory condition of childhood worldwide, with
around 14% of children and young people affected. Despite the high prevalence, paediatric …

Asthma is a complex respiratory disease that varies in severity and response to treatment.
Several asthma phenotypes with unique clinical and inflammatory characteristics have been …

Background: The fractional exhaled nitric oxide (FeNO) test is a point-of-care test that is
used in the assessment of asthma. Objective: To provide evidence-based clinical guidance …

Background Patients with severe, uncontrolled asthma have a significant unmet need for
new treatments that have broader effects on airway inflammation, and that provide greater …

Interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP) are alarmins that are
released upon airway epithelial injury from insults such as viruses and cigarette smoke, and …