Leukotrienes, a class of arachidonic acid–derived bioactive molecules, are known as
mediators of allergic and inflammatory reactions and considered to be important drug …

The skin is an organ involved in several biological processes essential to the proper
functioning of the organism. One of these essential biological functions of the skin is its …

Wound healing is an important process in the human body to protect against external
threats. A dysregulation at any stage of the wound healing process may result in the …

Trauma or infection can result in tissue damage, which needs to be repaired in a well‐
orchestrated manner to restore tissue function and homeostasis. Lipid mediators derived …

Abstract Leukotriene B 4 (LTB 4) is generated by the enzymatic oxidation of arachidonic
acid, which is then released from the cell membrane and acts as a potent activator of …

Summary Leukotriene B4 (LTB4) was recognized as an arachidonate‐derived chemotactic
factor for inflammatory cells and an important drug target even before the molecular …

Abstract The phospho-sphingolipid, ceramide 1-phosphate (C1P), has long been implicated
as a dynamic bioactive agent. Over two decades of research has begun to characterize …

Non-healing wounds are among the main causes of morbidity and mortality. We recently
described a novel, serum-free ex vivo expansion system, the quantity and quality culture …

Continuous integration of signals from the micro-and macro-environment is necessary for
somatic stem cells to adapt to changing conditions, maintain tissue homeostasis, and …

The sphingolipid ceramide 1-phosphate (C1P) directly binds to and activates group IVA
cytosolic phospholipase A2 (cPLA2α) to stimulate the production of eicosanoids. Because …