Long-term respiratory effects of mustard vesicants

R Malaviya, JD Laskin, DL Laskin - Toxicology letters, 2020 - Elsevier
Sulfur mustard and related vesicants are cytotoxic alkylating agents that cause severe
damage to the respiratory tract. Injury is progressive leading, over time, to asthma …

Targeting tumor necrosis factor alpha to mitigate lung injury induced by mustard vesicants and radiation

R Malaviya, JD Laskin, R Businaro… - Disaster medicine and …, 2023 - cambridge.org
Pulmonary injury induced by mustard vesicants and radiation is characterized by DNA
damage, oxidative stress, and inflammation. This is associated with increases in levels of …

[HTML][HTML] Downregulation of miR‑29b‑3p promotes α‑tubulin deacetylation by targeting the interaction of matrix metalloproteinase‑9 with integrin β1 in nasal polyps

Z Liu, H Liu, D Yu, J Gao… - … Journal of Molecular …, 2021 - spandidos-publications.com
Abstract Matrix metalloproteinase (MMP)‑9 is a key enzyme responsible for extracellular
matrix degradation and contributes to the progressive histological changes observed in …

Repetitive diacetyl vapor exposure promotes ubiquitin proteasome stress and precedes bronchiolitis obliterans pathology

J Wang, SY Kim, E House, HM Olson, CJ Johnston… - Archives of …, 2021 - Springer
Bronchiolitis obliterans (BO) is a devastating lung disease seen commonly after lung
transplant, following severe respiratory tract infection or chemical inhalation exposure …

Single-cell resolution of human airway epithelial cells exposed to bronchiolitis obliterans-associated chemicals

CY Chu, SY Kim, GS Pryhuber… - … of Physiology-Lung …, 2024 - journals.physiology.org
Bronchiolitis obliterans (BO) is a fibrotic lung disease characterized by progressive luminal
narrowing and obliteration of the small airways. In the nontransplant population, inhalation …

The immunomodulatory effects of mesenchymal stem cells on long term pulmonary complications in an animal model exposed to a sulfur mustard analog

S Sadeghi, N Mosaffa, SM Hashemi… - International …, 2020 - Elsevier
Abstract Introduction Sulfur Mustard (SM) is one of the most lethal chemicals with major
complications manifested in the lungs. Although the pathogenesis behind SM-induced lung …

Exogenous mesenchymal stem cells affect the function of endogenous lung stem cells (club cells) in phosgene-induced lung injury

K Ye, D He, Y Shao, N Xu, C Jin, L Zhang… - … and biophysical research …, 2019 - Elsevier
Exogenous mesenchymal stem cells (MSCs) affect lung cells via cytokines as well as
vesicles and activate the Notch signaling pathway thus affecting the proliferation of …

Mesenchymal Stem Cell Therapy Mitigates Acute and Chronic Lung Damages of Sulfur Mustard Analog Exposure

M Tapak, S Sadeghi, T Ghazanfari… - Iranian Journal of …, 2024 - ijaai.tums.ac.ir
Sulfur mustard (SM) is an established chemical weapon that can result in severe damage to
parts of the body. Currently, there are no effective treatments available for SM-caused …

Methyl isocyanate inhalation induces tissue factor-dependent activation of coagulation in rats

RC Rancourt, JS Rioux, LA Veress… - Drug and chemical …, 2019 - Taylor & Francis
Methyl isocyanate (MIC) is a highly toxic industrial chemical causing acute lethality after
inhalation. The objective of this study was to determine whether alterations in hemostasis …

Diacetyl inhalation impairs airway epithelial repair in mice infected with influenza A virus

MD McGraw, M Yee, SY Kim… - … of Physiology-Lung …, 2022 - journals.physiology.org
Bronchiolitis obliterans (BO) is a debilitating disease of the small airways that can develop
following exposure to toxic chemicals as well as respiratory tract infections. BO development …