Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight

JW Vogel, N Corriveau-Lecavalier… - Nature Reviews …, 2023 - nature.com
Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …

Questions and controversies in the study of time-varying functional connectivity in resting fMRI

DJ Lurie, D Kessler, DS Bassett, RF Betzel… - Network …, 2020 - direct.mit.edu
The brain is a complex, multiscale dynamical system composed of many interacting regions.
Knowledge of the spatiotemporal organization of these interactions is critical for establishing …

Global waves synchronize the brain's functional systems with fluctuating arousal

RV Raut, AZ Snyder, A Mitra, D Yellin, N Fujii… - Science …, 2021 - science.org
We propose and empirically support a parsimonious account of intrinsic, brain-wide
spatiotemporal organization arising from traveling waves linked to arousal. We hypothesize …

A tripartite view of the posterior cingulate cortex

BL Foster, SR Koslov, L Aponik-Gremillion… - Nature Reviews …, 2023 - nature.com
The posterior cingulate cortex (PCC) is one of the least understood regions of the cerebral
cortex. By contrast, the anterior cingulate cortex has been the subject of intensive …

Challenges and future directions for representations of functional brain organization

J Bijsterbosch, SJ Harrison, S Jbabdi, M Woolrich… - Nature …, 2020 - nature.com
A key principle of brain organization is the functional integration of brain regions into
interconnected networks. Functional MRI scans acquired at rest offer insights into functional …

[HTML][HTML] Hierarchical heterogeneity across human cortex shapes large-scale neural dynamics

M Demirtaş, JB Burt, M Helmer, JL Ji, BD Adkinson… - Neuron, 2019 - cell.com
The large-scale organization of dynamical neural activity across cortex emerges through
long-range interactions among local circuits. We hypothesized that large-scale dynamics are …

[HTML][HTML] What have we really learned from functional connectivity in clinical populations?

J Zhang, A Kucyi, J Raya, AN Nielsen, JS Nomi… - NeuroImage, 2021 - Elsevier
Functional connectivity (FC), or the statistical interdependence of blood-oxygen dependent
level (BOLD) signals between brain regions using fMRI, has emerged as a widely used tool …

[HTML][HTML] Connectomics of human electrophysiology

S Sadaghiani, MJ Brookes, S Baillet - NeuroImage, 2022 - Elsevier
We present both a scientific overview and conceptual positions concerning the challenges
and assets of electrophysiological measurements in the search for the nature and functions …

[HTML][HTML] Resting-state “physiological networks”

JE Chen, LD Lewis, C Chang, Q Tian, NE Fultz… - NeuroImage, 2020 - Elsevier
Slow changes in systemic brain physiology can elicit large fluctuations in fMRI time series,
which manifest as structured spatial patterns of temporal correlations between distant brain …

Dissociations between glucose metabolism and blood oxygenation in the human default mode network revealed by simultaneous PET-fMRI

LJ Stiernman, F Grill, A Hahn… - Proceedings of the …, 2021 - National Acad Sciences
The finding of reduced functional MRI (fMRI) activity in the default mode network (DMN)
during externally focused cognitive control has been highly influential to our understanding …