Drugs, host proteins and viral proteins: How their promiscuities shape antiviral design

MN Gupta, I Roy - Biological Reviews, 2021 - Wiley Online Library
The reciprocal nature of drug specificity and target specificity implies that the same is true for
their respective promiscuities. Protein promiscuity has two broadly different types of footprint …

Proteomic and biochemical assays of glutathione-related proteins in susceptible and multiple herbicide resistant Avena fatua L.

EE Burns, BK Keith, MY Refai, B Bothner… - Pesticide biochemistry …, 2017 - Elsevier
Extensive herbicide usage has led to the evolution of resistant weed populations that cause
substantial crop yield losses and increase production costs. The multiple herbicide resistant …

Redox‐regulated methionine oxidation of Arabidopsis thaliana glutathione transferase Phi9 induces H‐site flexibility

MA Tossounian, K Wahni, I Van Molle… - Protein …, 2019 - Wiley Online Library
Glutathione transferase enzymes help plants to cope with biotic and abiotic stress. They
mainly catalyze the conjugation of glutathione (GSH) onto xenobiotics, and some act as …

Dysregulation of RalA signaling through dual regulatory mechanisms exerts its oncogenic functions in hepatocellular carcinoma

L Tian, L Zhao, KMF Sze, CS Kam, VSI Ming… - Hepatology, 2022 - journals.lww.com
Conclusions Our results provide biological insight that dysregulation of RalA signaling
through dual regulatory mechanisms supports its oncogenic functions in HCC. Targeting …

Insights into ligand binding to a glutathione S-transferase from mango: Structure, thermodynamics and kinetics

I Valenzuela-Chavira, CA Contreras-Vergara… - Biochimie, 2017 - Elsevier
We studied a mango glutathione S-transferase (GST)(Mangifera indica) bound to
glutathione (GSH) and S-hexyl glutathione (GSX). This GST Tau class (MiGSTU) had a …

Amidase, a novel detoxifying enzyme, is involved in cyflumetofen resistance in Tetranychus cinnabarinus (Boisduval)

J Liu, Y Zhang, K Feng, X Liu, J Li, C Li, P Zhang… - Pesticide biochemistry …, 2020 - Elsevier
Amidase is an important hydrolytic enzyme in detoxification metabolism. Amidase
hydrolyzes a wide variety of nonpeptide carbon‑nitrogen bonds by attacking a cyano group …

Genome-wide analysis and transcript profiling identify several abiotic and biotic stress-responsive Glutathione S-transferase genes in soybean

MS Hasan, S Islam, MN Hasan, SD Sajib, S Ahmed… - Plant gene, 2020 - Elsevier
Abiotic and biotic stresses stimulate the generation of free radicals and reactive oxygen
species, which results in oxidative stress. Glutathione-S-transferase (GST) is a large class of …

Comparative structural and functional analysis of phi class glutathione transferases involved in multiple-herbicide resistance of grass weeds and crops

N Georgakis, N Poudel, AC Papageorgiou… - Plant physiology and …, 2020 - Elsevier
Multiple-herbicide resistant (MHR) weeds are a global problem and a looming threat to
weed control in crops. MHR weeds express a specific phi class glutathione transferase …

Comparative analyses and evaluation of the cosmeceutical potential of selected Chlorella strains

M Chatzikonstantinou, A Kalliampakou… - Journal of Applied …, 2017 - Springer
In the present study, aqueous extracts from eight Chlorella strains were evaluated towards
selected cosmeceutical properties such as enzymatic and non-enzymatic antioxidant …

Glutathione Transferases Are Involved in the Genotype-Specific Salt-Stress Response of Tomato Plants

E Horváth, K Kulman, B Tompa, ÁB Hajnal, A Pelsőczi… - Antioxidants, 2023 - mdpi.com
Glutathione transferases (GSTs) are one of the most versatile multigenic enzyme
superfamilies. In our experiments, the involvement of the genotype-specific induction of GST …