Vascular smooth muscle cells and arterial stiffening: relevance in development, aging, and disease

P Lacolley, V Regnault, P Segers… - Physiological …, 2017 - journals.physiology.org
The cushioning function of large arteries encompasses distension during systole and recoil
during diastole which transforms pulsatile flow into a steady flow in the microcirculation …

Sodium glucose cotransporter 2 inhibitors in the treatment of diabetes mellitus: cardiovascular and kidney effects, potential mechanisms, and clinical applications

HJL Heerspink, BA Perkins, DH Fitchett, M Husain… - Circulation, 2016 - Am Heart Assoc
Sodium-glucose cotransporter-2 (SGLT2) inhibitors, including empagliflozin, dapagliflozin,
and canagliflozin, are now widely approved antihyperglycemic therapies. Because of their …

Recommendations for improving and standardizing vascular research on arterial stiffness: a scientific statement from the American Heart Association

RR Townsend, IB Wilkinson, EL Schiffrin, AP Avolio… - …, 2015 - Am Heart Assoc
Townsend et al Vascular Research on Arterial Stiffness 699 pressure, blood flow, and
arterial diameter change with each heartbeat. In addition to the passive mechanical …

[HTML][HTML] The role of vascular biomarkers for primary and secondary prevention. A position paper from the European Society of Cardiology Working Group on …

C Vlachopoulos, P Xaplanteris, V Aboyans… - Atherosclerosis, 2015 - Elsevier
While risk scores are invaluable tools for adapted preventive strategies, a significant gap
exists between predicted and actual event rates. Additional tools to further stratify the risk of …

Central blood pressure: current evidence and clinical importance

CM McEniery, JR Cockcroft, MJ Roman… - European heart …, 2014 - academic.oup.com
Pressure measured with a cuff and sphygmomanometer in the brachial artery is accepted as
an important predictor of future cardiovascular risk. However, systolic pressure varies …

The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type 1 diabetes mellitus

DZI Cherney, BA Perkins, N Soleymanlou… - Cardiovascular …, 2014 - Springer
Background Individuals with type 1 diabetes mellitus are at high risk for the development of
hypertension, contributing to cardiovascular complications. Hyperglycaemia-mediated …

Arterial stiffness, the brain and cognition: a systematic review

J Singer, JN Trollor, BT Baune, PS Sachdev… - Ageing research …, 2014 - Elsevier
Background Arterial stiffness is a known predictor of cardiovascular disease, and has also
been associated with markers of cerebral small vessel disease as well as poor cognitive …

Arterial stiffness and hypertension: emerging concepts

RA Payne, IB Wilkinson, DJ Webb - Hypertension, 2010 - Am Heart Assoc
Arterial stiffness is increasingly recognized as an impor-tant prognostic index and potential
therapeutic target in patients with hypertension. It is closely linked to, but by no means …

Angiotensin converting enzyme inhibitors effect on arterial stiffness and wave reflections: a meta-analysis and meta-regression of randomised controlled trials

Y Shahin, JA Khan, I Chetter - Atherosclerosis, 2012 - Elsevier
OBJECTIVE: Several studies have assessed the effect of angiotensin converting enzyme
inhibitors (ACEIs) on arterial stiffness and wave reflections as measured by pulse wave …

Mechanisms of vascular calcification in CKD—evidence for premature ageing?

CM Shanahan - Nature Reviews Nephrology, 2013 - nature.com
Ageing is a potent, independent risk factor for cardiovascular disease. Calcification of the
vascular smooth muscle cell (VSMC) layer of the vessel media is a hallmark of vascular …