Schizophrenia is recognized to be a highly heterogeneous disease at various levels, from
genetics to clinical manifestations and treatment sensitivity. This heterogeneity is also …

Primary dissociated neuronal cultures have been intensively exploited for the past 15 years
as model systems to investigate excitotoxic neuronal degeneration. Even this simplified …

purpose. Oxidative stress is increased in the retina in diabetes, and antioxidants inhibit
activation of caspase-3 and the development of retinopathy. The purpose of this study was to …

Apoptosis is characterized by chromatin condensation, phosphatidylserine translocation,
and caspase activation. Neuronal apoptotic death involves the participation of reactive …

Microglia are specialized phagocytes in the vertebrate central nervous system (CNS). As the
resident immune cells of the CNS they play an important role in the removal of dying …

Oxidative stress contributes to neurodegeneration in Huntington's disease (HD). However,
the origins of oxidative stress in HD remain unclear. Studies in HD transgenic models …

Stroke is a life-threatening disease characterized by rapidly developing clinical signs of focal
or global disturbance of cerebral function due to cerebral ischemia. A number of flavonoids …

In utero ethanol exposure elicits apoptotic cell death in the fetal brain, and this may be
mediated by oxidative stress. Our studies utilize cultured fetal rat cortical neurons and …

D-galactose, a reducing sugar, induces oxidative stress resulting in alteration in
mitochondrial dynamics and apoptosis of neurons. Curcumin and hesperidin are …

The endocannabinoid system (ECS) and reactive oxygen species (ROS) constitute two key
cellular signalling systems that participate in the modulation of diverse cellular functions …