Interactions of signaling proteins, growth factors and other proteins with heparan sulfate: mechanisms and mysteries
PC Billings, M Pacifici - Connective tissue research, 2015 - Taylor & Francis
Heparan sulfate (HS) is a component of cell surface and matrix-associated proteoglycans
(HSPGs) that, collectively, play crucial roles in many physiologic processes including cell …
(HSPGs) that, collectively, play crucial roles in many physiologic processes including cell …
Toward the next generation of vascularized human neural organoids
M Li, L Gao, L Zhao, T Zou, H Xu - Medicinal research reviews, 2023 - Wiley Online Library
Thanks to progress in the development of three‐dimensional (3D) culture technologies,
human central nervous system (CNS) development and diseases have been gradually …
human central nervous system (CNS) development and diseases have been gradually …
Inhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple-negative breast cancer
Although blocking the binding of vascular endothelial growth factor (VEGF) to neuropilin-2
(NRP2) on tumor cells is a potential strategy to treat aggressive carcinomas, a lack of …
(NRP2) on tumor cells is a potential strategy to treat aggressive carcinomas, a lack of …
Whole-genome and transcriptome sequencing of prostate cancer identify new genetic alterations driving disease progression
Background Global disparities in prostate cancer (PCa) incidence highlight the urgent need
to identify genomic abnormalities in prostate tumors in different ethnic populations including …
to identify genomic abnormalities in prostate tumors in different ethnic populations including …
Neuropilins in the context of tumor vasculature
S Niland, JA Eble - International journal of molecular sciences, 2019 - mdpi.com
Neuropilin-1 and Neuropilin-2 form a small family of plasma membrane spanning receptors
originally identified by the binding of semaphorin and vascular endothelial growth factor …
originally identified by the binding of semaphorin and vascular endothelial growth factor …
A pan-cancer study of class-3 semaphorins as therapeutic targets in cancer
Background Initially characterized as axon guidance factors, semaphorins also have been
implicated to have critical roles in multiple physiological and developmental functions …
implicated to have critical roles in multiple physiological and developmental functions …
Emerging roles and mechanisms of semaphorins activity in cancer
Semaphorins are regulatory molecules that are linked to the modulation of several cancer
processes, such as angiogenesis, cancer cell invasiveness and metastasis, tumor growth …
processes, such as angiogenesis, cancer cell invasiveness and metastasis, tumor growth …
Secreted primary human malignant mesothelioma exosome signature reflects oncogenic cargo
Malignant mesothelioma (MM) is a highly-aggressive heterogeneous malignancy, typically
diagnosed at advanced stage. An important area of mesothelioma biology and progression …
diagnosed at advanced stage. An important area of mesothelioma biology and progression …
Phytochemicals targeting VEGF and VEGF-related multifactors as anticancer therapy
The role of vascular endothelial growth factor (VEGF) in cancer cells is not limited to
angiogenesis; there are also multiple factors, such as neuropilins (non-tyrosine kinases …
angiogenesis; there are also multiple factors, such as neuropilins (non-tyrosine kinases …
PI4KIIIβ is a therapeutic target in chromosome 1q–amplified lung adenocarcinoma
Heightened secretion of protumorigenic effector proteins is a feature of malignant cells. Yet,
the molecular underpinnings and therapeutic implications of this feature remain unclear …
the molecular underpinnings and therapeutic implications of this feature remain unclear …