Ageing is an inevitable event in the lifecycle of all organisms, characterized by progressive
physiological deterioration and increased vulnerability to death. Ageing has also been …

Reactive oxygen or nitrogen species (ROS, RNS) and oxidative stress in the respiratory
system increase the production of mediators of pulmonary inflammation and initiate or …

Programmed cell death (PCD) pathways, including apoptosis and regulated necrosis, are
required for normal cell turnover and tissue homeostasis. Mis-regulation of PCD is …

The transcription factor, p53, is critical for many important cellular functions involved in
genome integrity, including cell cycle control, DNA damage response, and apoptosis …

Several epidemiological studies show an inverse association between cancer and
Alzheimer's disease (AD). It is debated whether this association is the consequence of …

Alzheimers disease (AD) is the most common age-related dementia. Among its major
challenges is identifying molecular signatures characteristic for the early AD stage in …

The p53 tumor suppressor plays a central role in dictating cell survival and death as a
cellular sensor for a myriad of stresses including DNA damage, oxidative and nutritional …

Referred to as the “guardian of the genome”, p53 is the most frequently mutated protein in
cancer and almost all cancers exhibit malfunction along the p53 pathway. As an …

The negative association between Alzheimer's disease (AD) and cancer suggests that
susceptibility to one disease may protect against the other. When biological mechanisms of …

Heterogenous nuclear ribonucleoproteins (hnRNPs) are a complex and functionally diverse
family of RNA binding proteins with multifarious roles. They are involved, directly or …