Natural antisense transcripts (NATs) have been shown to play important roles in post-
transcriptional regulation through the RNA interference pathway. We have combined …

Alzheimer's disease (AD) is an aberrant aging process characterized by progressive decline
in cognition and dramatic behavioral changes. AD has no treatment to slow or halt its …

Alzheimer's disease (AD) is a multifactorial syndrome, with a complex interplay of genetic
and biochemical factors contributing to the cognitive decline. Besides diffuse neuronal loss …

Noise-induced hearing loss (NIHL) is a global health problem affecting up to 5% of the
population worldwide. In many instances, NIHL results from acute exposure to traumatic …

As a deubiquitinating enzyme (DUB), the physiological substrates of ataxin-3 (ATX-3)
remain elusive, which limits our understanding of its normal cellular function and that of …

Epithelial cell lines, RTgill-W1 and RTL-W1 from respectively the gill and liver of rainbow
trout, Onchorhynchus mykiss (Walbum), were used to investigate the role of p53 in the …

The goal of this dissertation is to further understand two key, broad processes which occur
over the course of a neuron's lifetime: its development and possible degeneration in …

Mounting evidence points to a role for endogenous reactive oxygen species (ROS) in cell
signalling, including in cell proliferation, differentiation and fate. However, the function of …

Colorectal cancer is one of the leading causes of cancer death worldwide and it is
associated with aberrant cycle progression and defective apoptosis induction due to the …

Reprogramming healthy somatic cells into disease-relevant cell types through cellular
reprogramming has been intensively investigated. The discovery of reprogramming methods …