PP2A as a master regulator of the cell cycle
N Wlodarchak, Y Xing - Critical reviews in biochemistry and …, 2016 - Taylor & Francis
Abstract Protein phosphatase 2A (PP2A) plays a critical multi-faceted role in the regulation
of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell …
of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell …
Cellular processing of platinum anticancer drugs
D Wang, SJ Lippard - Nature reviews Drug discovery, 2005 - nature.com
Cisplatin, carboplatin and oxaliplatin are platinum-based drugs that are widely used in
cancer chemotherapy. Platinum–DNA adducts, which are formed following uptake of the …
cancer chemotherapy. Platinum–DNA adducts, which are formed following uptake of the …
Biochemical mechanisms of cisplatin cytotoxicity
V Cepeda, MA Fuertes, J Castilla… - Anti-Cancer Agents …, 2007 - ingentaconnect.com
Since the discovery by Rosenberg and collaborators of the antitumor activity of cisplatin 35
years ago, three platinum antitumor drugs (cisplatin, carboplatin and oxaliplatin) have …
years ago, three platinum antitumor drugs (cisplatin, carboplatin and oxaliplatin) have …
Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer
T Boutros, E Chevet, P Metrakos - Pharmacological reviews, 2008 - ASPET
Mitogen-activated protein kinase dual-specificity phosphatase-1 (also called MKP-1,
DUSP1, ERP, CL100, HVH1, PTPN10, and 3CH134) is a member of the threonine-tyrosine …
DUSP1, ERP, CL100, HVH1, PTPN10, and 3CH134) is a member of the threonine-tyrosine …
The stress-activated protein kinase pathways
LA Tibbles, JR Woodgett - Cellular and Molecular Life Sciences CMLS, 1999 - Springer
Part of the cellular response to toxins, physical stresses and inflammatory cytokines occurs
by signalling via the stress-activated protein kinase (SAPK) and p38 reactivating kinase …
by signalling via the stress-activated protein kinase (SAPK) and p38 reactivating kinase …
MAP kinase pathways activated by stress: the p38 MAPK pathway
T Obata, GE Brown, MB Yaffe - Critical care medicine, 2000 - journals.lww.com
A stress-activated serine/threonine protein kinase, p38 mitogen-activated protein kinase
(p38 MAPK), belongs to the MAP kinase superfamily. Diverse extracellular stimuli, including …
(p38 MAPK), belongs to the MAP kinase superfamily. Diverse extracellular stimuli, including …
Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38
M Lasa, SM Abraham, C Boucheron… - … and cellular biology, 2002 - Am Soc Microbiol
The stress-activated protein kinase p38 stabilizes a number of mRNAs encoding
inflammatory mediators, such as cyclooxygenase 2 (Cox-2). In HeLa cells the anti …
inflammatory mediators, such as cyclooxygenase 2 (Cox-2). In HeLa cells the anti …
Druggable cancer phosphatases
The phosphorylation status of oncoproteins is regulated by both kinases and phosphatases.
Kinase inhibitors are rarely sufficient for successful cancer treatment, and phosphatases …
Kinase inhibitors are rarely sufficient for successful cancer treatment, and phosphatases …
[HTML][HTML] Dual-specificity MAP kinase phosphatases in health and disease
It is well established that a family of dual-specificity MAP kinase phosphatases (MKPs) play
key roles in the regulated dephosphorylation and inactivation of MAP kinase isoforms in …
key roles in the regulated dephosphorylation and inactivation of MAP kinase isoforms in …
Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1
KL Jeffrey, T Brummer, MS Rolph, SM Liu… - Nature …, 2006 - nature.com
Mitogen-activated protein kinases facilitate many cellular processes and are essential for
immune cell function. Their activity is controlled by kinases and dual-specificity …
immune cell function. Their activity is controlled by kinases and dual-specificity …