Ionic liquids are remarkable chemical compounds, which find applications in many areas of
modern science. Because of their highly tunable nature and exceptional properties, ionic …

Single-entity electrochemistry (SEE) describes a recent trend in state-of-the-art
electrochemistry applied to the study of individual “things.” Conceptually, SEE covers …

The implementation of a reliable, rapid, inexpensive, and simple method for whole-proteome
identification would greatly benefit cell biology research and clinical medicine. Proteins are …

Detecting target analytes with high specificity and sensitivity in any fluid is of fundamental
importance to analytical science and technology. Surface-enhanced Raman scattering …

This Perspective focuses on the latest strategies and challenges for the development of
bioanalytical sensors with sub-picomolar detection limits. Achieving sub-picomolar detection …

Nanopore techniques offer a low-cost, label-free, and high-throughput platform that could be
used in single-molecule biosensing and in particular DNA sequencing. Since 2010 …

Protein nanopores offer an inexpensive, label-free method of analysing single
oligonucleotides. The sensitivity of the approach is largely determined by the characteristics …

Membrane nanopores—hollow nanoscale barrels that puncture biological or synthetic
membranes—have become powerful tools in chemical-and biosensing, and have achieved …

Nanopore-based sensors typically work by monitoring transient pulses in conductance via
current–time traces as molecules translocate through the nanopore. The unique property of …

Both scientists and engineers are interested in the design andfabrication of synthetic
nanofluidic architectures that mimic the gating functions of biological ion channels. The effort …