Laboratory models, both animal and human, have made enormous contributions to our
understanding of addiction. For addictive disorders, animal models have the great …

Insights into the Role of Dopamine Receptor Systems in Learning and Memory Page 1 ©
Freund & Pettman, UK Reviews in the Neurosciences, 18, 37-66 (2007) Insights into the Role …

Development of drug addiction involves persistent neurobiological changes. The dopamine
D1 receptor is involved in mediating cocaine-induced neuroadaptation, yet the underlying …

Cannabinoids are postulated to play a role in modulating the reinforcing effects of abused
drugs, including alcohol. Experiment 1 examined alcohol self-administration in cannabinoid …

Abstract Dopamine (DA) D2 receptor (D2R) agonists and antagonists can modulate self‐
administration behavior, conditioned place preference, and locomotor responses to cocaine …

In rats, acute administration of SB‐277011A, a highly selective dopamine (DA) D3 receptor
antagonist, blocks cocaine‐enhanced brain stimulation reward, cocaine‐seeking behaviour …

We applied a sensitive new functional magnetic resonance imaging technique to identify the
pattern and determinants of cocaine-induced brain activation in drug-naive rats. At doses …

In the search for efficacious pharmacotherapies to treat cocaine addiction much attention
has been given to agents targeting dopamine D1 or D3 receptors because of the …

Although the protective effects of social bonds on drug use/abuse have been well
documented, we know little about the underlying neural mechanisms. Using the prairie vole …

Abstract Rationale Dopamine D1 receptor (D1R) signaling has been associated to ethanol
consumption and reward in laboratory animals. Objectives Here, we hypothesize that this …