Rationale Experimental evidence indicates that the mesolimbic dopamine (DA) pathway
innervating the ventral striatum is critically involved in the motivational effects of drug abuse …

Psychostimulant‐induced locomotor hyperactivity is commonly associated with an inhibition
of dopamine reuptake. However, a physiological coupling between noradrenergic and …

Increasing evidence suggests that enhanced dopamine (DA) neurotransmission in the
nucleus accumbens (NAc) may play a role in mediating the reward and reinforcement …

Environment‐induced relapse is a major concern in drug addiction because of the strong
associations formed between drug reward and environment. Cocaine‐conditioned place …

The goal of this study was to determine D 1 receptor availability in human cocaine-
dependent (CD) subjects and matched healthy controls (HCs). In addition, the CD subjects …

Food restriction has been shown to increase self‐administration of psychostimulants,
including cocaine and amphetamine (AMPH). Consistent with this, food‐restricted rats are …

Recent studies demonstrated that vesicular dopamine (DA) uptake can be rapidly altered in
synaptic vesicles purified from the striata of stimulant-treated rats. Specifically, a single …

Addiction is a chronic, relapsing disease of the brain that includes drug-induced compulsive
seeking behavior and consumption of drugs. Dopamine (DA) is considered to be critical in …

These studies examined the roles of dopamine D1-and D2-like receptors within the nucleus
accumbens (Acb) in the acquisition and expression of ethanol-induced (2 g/kg) conditioned …

Rationale Drugs of abuse are initially used because of their rewarding properties. As a result
of repeated drug exposure, sensitization to certain behavioral effects of drugs occurs, which …