In a previous report, we identified a novel molecule, SHATI/NAT8L, having an inhibitory
effect on methamphetamine (METH)-induced hyperlocomotion, sensitization, and …

Background Clock genes have been demonstrated to play a role in behavioral responses to
a variety of drugs of abuse, including cocaine, amphetamine, morphine, and ethanol …

Exposure to drugs of abuse activates gene expression and protein synthesis that result in
long‐lasting adaptations in striatal signaling. Therefore, identification of the transcription …

Experimental manipulation of dopamine (DA) transmission by lesions and drugs indicates a
role in the acquisition and expression of behavior motivated by conventional and drug …

Chronic use of psychostimulants induces enduringly increased responsiveness to a
subsequent psychostimulant injection and sensitivity to drug-associated cues, contributing to …

Background: In the present study, the effects of intra-basolateral amygdala (BLA) blockade
of dopamine D1 receptor on morphine-induced conditioned place preference (CPP) were …

The purpose of this study was to investigate the effects of (-)-stepholidine (SPD), a
compound with dopamine D1 partial agonist and D2/D3 antagonist properties, on the …

Rationale Relapse is a primary obstacle in the treatment of addiction disorders, and as such,
understanding this phenomenon is a major effort of clinical and preclinical studies of …

A major criticism of the place conditioning procedure for studying conditioned drug reward is
that it is relatively insensitive to large quantitative shifts in drug dose (ie, dose effects are all …

Abstract Disrupted-in-Schizophrenia 1 (DISC1) is a scaffold protein implicated in various
psychiatric diseases. Dysregulation of the dopamine system has been associated with …