Hereditary non-polyposis colorectal cancer (HNPCC) was previously synonymous with
Lynch syndrome; however, identification of the role of germline mutations in the DNA …

Understanding of the mechanism of colorectal carcinogenesis has been gaining momentum
for some years on account of its high incidence and impact on the lives of individuals …

Objective The objectives of the current study were to examine the trends in incidence rates
of subsite-specific colorectal cancer at all stages in a large US population and to explore the …

Abstract Background and Aim: Recently, the clinical and biological differences between right‐
and left‐sided colon cancers have been widely debated. However, close analyses of these …

Epigenetic alterations, such as abnormal DNA-methylation patterns, are associated with
many human tumour types. New techniques have been developed to perform genome-wide …

Identification of microsatellite unstable (MSI-H) colorectal cancers (CRCs) is important not
only for the identification of hereditary nonpolyposis colorectal cancer syndrome but also …

Background: The objective of the study was to examine the role of microsatellite instability
(MSI) and BRAF V600E mutation in colorectal cancer (CRC) by categorising patients into …

Colorectal carcinomas (CRCs) with high microsatellite instability (MSI-H) share
clinicopathological features distinctly different from their microsatellite stable (MSS) …

Microsatellite instability (MSI) occurs in 10% to 20% of colorectal cancers (CRC) and has
been attributed to both MLH1 promoter hypermethylation and germline mutation in the …

Since the MOSAIC study, oxaliplatin-based adjuvant chemotherapy has been the standard
treatment of stage III colon cancer. Combination therapy with fluoropyrimidines and …