Ewing sarcoma, a highly aggressive bone and soft-tissue cancer, is considered a prime
example of the paradigms of a translocation-positive sarcoma: a genetically rather simple …

Genomic-based precision medicine has not only improved tumour therapy but has also
shown its weaknesses. Genomic profiling and mutation analysis have identified alterations …

Abstract PD-1 blockade (nivolumab) efficacy remains modest for metastatic sarcoma. In this
paper, we present an open-label, non-randomized, non-comparative pilot study of …

Objective Development and validation of a radiomics nomogram for predicting recurrence
and adjuvant therapy benefit populations in high/intermediate-risk gastrointestinal stromal …

Aims NTRK gene fusions have been described in a wide variety of central nervous system
(CNS) and soft tissue tumours, including the provisional tumour type 'spindle cell neoplasm …

Background: Lung cancer represents a heterogeneous group of neoplasms, with the highest
frequency and mortality in both sexes combined. In a clinical scenario characterized by the …

Rhabdomyosarcoma (RMS) is a malignant tumour of the soft tissues. There are two main
histopathological types: alveolar and embryonal. RMS occurs mainly in childhood and is a …

Progress in our understanding of the pathogenesis and diagnosis of soft tissue neoplasia is
exceptionally rapid. Although the most recent World Health Organization classification of soft …

Background Data on clinical outcomes for base of skull (BOS) chordomas in the pediatric
population is limited. We report patient outcomes after surgery and proton radiotherapy …

Objective This study aims to develop and validate the performance of an unenhanced
magnetic resonance imaging (MRI)-based combined radiomics nomogram for discrimination …