Glycosaminoglycans (GAGs) play a crucial role in tissue homeostasis by regulating the
activity and diffusion of bioactive molecules. Incorporating GAGs into biomaterials has …

Osteoarthritis (OA) is a multifaceted disease characterized by imbalances in extracellular
matrix metabolism, chondrocyte and synoviocyte senescence, as well as inflammatory …

The tyrosine kinase family receptor of discoidin domain receptors (DDR1 and DDR2) is
known to be activated by extracellular matrix collagen catalytic binding protein receptors …

Purpose Articular cartilage is vulnerable to multiple types of damage and it has limited
reparative and regenerative capacities due to its absence of vascularity. Although a large …

This study performs an analysis that will enable the evaluation of the quality, durability, and
structure of repaired cartilaginous extracellular matrix tissue using an autologous-based …

With the increasing incidence of osteoarthritis (OA) in elderly patients and the challenges
posed by its multifaceted pathogenesis in developing effective treatments, this study …

Glycosaminoglycans (GAGs) are ubiquitous components in the cartilage extracellular matrix
(ECM). Ultrastructural arrangement of ECM and GAG-mediated interactions with collagen …

To address the long-lasting challenges on repair of articular cartilage defects in clinic,
cartilage tissue engineering (CTE) strategy aims to develop favorable scaffolds to undertake …

Adults with spinal cord injury (SCI), a destructive neurological injury, have a significantly
higher incidence of osteoarthritis (OA), a highly prevalent chronic joint disorder. This study …

The essential functions of cartilage, such as shock absorption and resilience, are hindered
by its limited regenerative capacity. Although current therapies alleviate symptoms, novel …