GABA is the most common inhibitory neurotransmitter in the vertebrate central nervous
system. Synthesized by glutamic acid decarboxylase, GABA could specifically bind with two …

Paralleling advances with respect to more common antibody-mediated encephalitides, such
as anti-N-methyl-D-aspartate receptor (NMDAR) and anti-leucine-rich glioma-inactivated 1 …

Phasic (fast) and tonic (sustained) inhibition of γ-aminobutyric acid (GABA) are fundamental
for regulating day-to-day activities, neuronal excitability, and plasticity. However, the …

G-protein coupled receptors (GPCRs), one of the largest superfamilies of cell-surface
receptors, are heptahelical integral membrane proteins that play critical roles in virtually …

The main neurotransmitter in the brain responsible for the inhibition of neuronal activity is γ-
aminobutyric acid (GABA). It plays a crucial role in circuit formation during development …

Osteoporosis is a significant global health concern, linked to reduced bone density and an
increased fracture risk, with effective treatments still lacking. This study explored the …

Rheumatoid arthritis (RA) is a highly disabling chronic autoimmune disease. Multiple factors
contribute to the complex pathological process of RA, in which an abnormal autoimmune …

Aging causes functional decline and degeneration of neurons and is a major risk factor of
neurodegenerative diseases. To investigate the molecular mechanisms underlying neuronal …

GABA B receptors are obligatory heterodimers responsible for prolonged neuronal inhibition
in the central nervous system. The two receptor subunits are encoded by GABBR1 and …

BACKGROUND The association between diabetes mellitus (DM) and the increased risk and
progression of cholangiocarcinoma (CCA) has been reported with unclear underlying …