Covering: up to the beginning of 2020 Enzymes depending on cofactors are essential in
many biosynthetic pathways of natural products. They are often involved in key steps …

With the recognition in the 1960s and 1970s of the periodontopathic importance of the
microbial biofilm and its specific anaerobic microorganisms, periodontitis was treated as an …

Here we report the development of a proteolysis targeting chimera (PROTAC) based on the
combination of the unique features of the sirtuin rearranging ligands (SirReals) as highly …

Abstract BACKGROUND Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases
that catalyze post-translational modifications of proteins. Together, they respond to …

Sepsis-associated encephalopathy (SAE) is a cognitive impairment associated with sepsis
that occurs in the absence of direct infection in the central nervous system or structural brain …

Chemotherapy failure is the major cause of recurrence and poor prognosis in colorectal
cancer (CRC) patients. The role of the differentially expressed lncRNAs in 5-Fluorouracil …

Allosteric modulators bound to structurally diverse allosteric sites can achieve better
pharmacological advantages than orthosteric ligands. The discovery of allosteric …

Epigenetics refers to the DNA chemistry changes that result in the modification of gene
transcription and translation independently of the underlying DNA coding sequence …

Background: Sepsis-induced cardiomyopathy (SIC) is a severe myocardial dysfunction
secondary to septicemia. It is a major concern owing to the high mortality and morbidity …

Alzheimer's disease (AD) is the most common form of dementia affecting people mainly in
their sixth decade of life and at a higher age. It is an extensively studied neurodegenerative …