The interplay between chromatin, transcription factors and genes generates complex
regulatory circuits that can be represented as gene regulatory networks (GRNs). The study …

Highlights•The accessibility to automated flow cytometry equipment has recently been
increased through the open science initiative.•Automated and reactive flow cytometry can be …

The operation of the central metabolism is typically assumed to be deterministic, but
dynamics and high connectivity of the metabolic network make it potentially prone to …

Stochastic protein accumulation up to some concentration threshold sets the timing of many
cellular physiological processes. Here we obtain the exact distribution of first threshold …

MicroRNAs have been found to be necessary for regulating genes implicated in almost all
signaling pathways, and consequently their dysfunction influences many diseases, including …

In the stochastic description of biochemical reaction systems, the time evolution of statistical
moments for species population counts is described by a linear dynamical system. However …

The linear framework uses finite, directed graphs with labelled edges to model biomolecular
systems. Graph vertices represent chemical species or molecular states, edges represent …

How the noisy expression of regulatory proteins affects timing of intracellular events is an
intriguing fundamental problem that influences diverse cellular processes. Here we use the …

Cells are the fundamental units of life, and like all life forms, they change over time. Changes
in cell state are driven by molecular processes; of these many are initiated when molecule …

Many cellular events occur when their corresponding regulatory proteins attain critical
thresholds. Can cells schedule such events with precision by controlling the dynamics of the …