DNA hypermethylation in disease: mechanisms and clinical relevance
M Ehrlich - Epigenetics, 2019 - Taylor & Francis
Increasing numbers of studies implicate abnormal DNA methylation in cancer and many non-
malignant diseases. This is consistent with numerous findings about differentiation …
malignant diseases. This is consistent with numerous findings about differentiation …
[HTML][HTML] Oxidative stress and inflammation in osteoporosis: molecular mechanisms involved and the relationship with microRNAs
T Iantomasi, C Romagnoli, G Palmini, S Donati… - International journal of …, 2023 - mdpi.com
Osteoporosis is characterized by the alteration of bone homeostasis due to an imbalance
between osteoclastic bone resorption and osteoblastic bone formation. Estrogen deficiency …
between osteoclastic bone resorption and osteoblastic bone formation. Estrogen deficiency …
[HTML][HTML] Autophagy in bone homeostasis and the onset of osteoporosis
Autophagy is an evolutionarily conserved intracellular process, in which domestic cellular
components are selectively digested for the recycling of nutrients and energy. This process …
components are selectively digested for the recycling of nutrients and energy. This process …
Osteoclast-derived miR-23a-5p-containing exosomes inhibit osteogenic differentiation by regulating Runx2
JX Yang, P Xie, YS Li, T Wen, XC Yang - Cellular signalling, 2020 - Elsevier
Abstract Background Some microRNAs (miRNAs) are involved in osteogenic differentiation.
In recent years, increasing evidences have revealed that exosomes contain specific …
In recent years, increasing evidences have revealed that exosomes contain specific …
The role of miR‐29 family in disease
M Horita, C Farquharson… - Journal of cellular …, 2021 - Wiley Online Library
MicroRNAs are small noncoding RNAs that can bind to the target sites in the 3'‐untranslated
region of messenger RNA to regulate posttranscriptional gene expression. Increasing …
region of messenger RNA to regulate posttranscriptional gene expression. Increasing …
The role of autophagy in bone homeostasis
YF Guo, T Su, M Yang, C Li, Q Guo… - Journal of cellular …, 2021 - Wiley Online Library
Autophagy is an evolutionarily conserved intracellular process and is considered one of the
main catabolism pathways. In the process of autophagy, cells are digested nonselectively or …
main catabolism pathways. In the process of autophagy, cells are digested nonselectively or …
[HTML][HTML] METTL3 modulates osteoclast differentiation and function by controlling RNA stability and nuclear export
D Li, L Cai, R Meng, Z Feng, Q Xu - International Journal of Molecular …, 2020 - mdpi.com
Osteoclast differentiation and function are crucial for maintaining bone homeostasis and
preserving skeletal integrity. N6-methyladenosine (m6A) is an abundant mRNA modification …
preserving skeletal integrity. N6-methyladenosine (m6A) is an abundant mRNA modification …
The emerging role of microRNAs in bone remodeling and its therapeutic implications for osteoporosis
Q Feng, S Zheng, J Zheng - Bioscience reports, 2018 - portlandpress.com
Osteoporosis, a common and multifactorial disease, is influenced by genetic factors and
environments. However, the pathogenesis of osteoporosis has not been fully elucidated yet …
environments. However, the pathogenesis of osteoporosis has not been fully elucidated yet …
[HTML][HTML] New insights into the epigenetics of osteoporosis
JG Letarouilly, O Broux, A Clabaut - Genomics, 2019 - Elsevier
Osteoporosis is characterized by reduced bone formation and accumulation of adipocytes in
the bone marrow compartment. The decrease in bone mass results from an imbalance …
the bone marrow compartment. The decrease in bone mass results from an imbalance …
Epigenetic regulation of bone remodeling by natural compounds
Osteoporosis and osteopenia impact more than 54 million Americans, resulting in significant
morbidity and mortality. Alterations in bone remodeling are the hallmarks for osteoporosis …
morbidity and mortality. Alterations in bone remodeling are the hallmarks for osteoporosis …