DNA hypermethylation in disease: mechanisms and clinical relevance

M Ehrlich - Epigenetics, 2019 - Taylor & Francis
Increasing numbers of studies implicate abnormal DNA methylation in cancer and many non-
malignant diseases. This is consistent with numerous findings about differentiation …

[HTML][HTML] Oxidative stress and inflammation in osteoporosis: molecular mechanisms involved and the relationship with microRNAs

T Iantomasi, C Romagnoli, G Palmini, S Donati… - International journal of …, 2023 - mdpi.com
Osteoporosis is characterized by the alteration of bone homeostasis due to an imbalance
between osteoclastic bone resorption and osteoblastic bone formation. Estrogen deficiency …

[HTML][HTML] Autophagy in bone homeostasis and the onset of osteoporosis

X Yin, C Zhou, J Li, R Liu, B Shi, Q Yuan, S Zou - Bone research, 2019 - nature.com
Autophagy is an evolutionarily conserved intracellular process, in which domestic cellular
components are selectively digested for the recycling of nutrients and energy. This process …

Osteoclast-derived miR-23a-5p-containing exosomes inhibit osteogenic differentiation by regulating Runx2

JX Yang, P Xie, YS Li, T Wen, XC Yang - Cellular signalling, 2020 - Elsevier
Abstract Background Some microRNAs (miRNAs) are involved in osteogenic differentiation.
In recent years, increasing evidences have revealed that exosomes contain specific …

The role of miR‐29 family in disease

M Horita, C Farquharson… - Journal of cellular …, 2021 - Wiley Online Library
MicroRNAs are small noncoding RNAs that can bind to the target sites in the 3'‐untranslated
region of messenger RNA to regulate posttranscriptional gene expression. Increasing …

The role of autophagy in bone homeostasis

YF Guo, T Su, M Yang, C Li, Q Guo… - Journal of cellular …, 2021 - Wiley Online Library
Autophagy is an evolutionarily conserved intracellular process and is considered one of the
main catabolism pathways. In the process of autophagy, cells are digested nonselectively or …

[HTML][HTML] METTL3 modulates osteoclast differentiation and function by controlling RNA stability and nuclear export

D Li, L Cai, R Meng, Z Feng, Q Xu - International Journal of Molecular …, 2020 - mdpi.com
Osteoclast differentiation and function are crucial for maintaining bone homeostasis and
preserving skeletal integrity. N6-methyladenosine (m6A) is an abundant mRNA modification …

The emerging role of microRNAs in bone remodeling and its therapeutic implications for osteoporosis

Q Feng, S Zheng, J Zheng - Bioscience reports, 2018 - portlandpress.com
Osteoporosis, a common and multifactorial disease, is influenced by genetic factors and
environments. However, the pathogenesis of osteoporosis has not been fully elucidated yet …

[HTML][HTML] New insights into the epigenetics of osteoporosis

JG Letarouilly, O Broux, A Clabaut - Genomics, 2019 - Elsevier
Osteoporosis is characterized by reduced bone formation and accumulation of adipocytes in
the bone marrow compartment. The decrease in bone mass results from an imbalance …

Epigenetic regulation of bone remodeling by natural compounds

N Raut, SM Wicks, TO Lawal, GB Mahady - Pharmacological research, 2019 - Elsevier
Osteoporosis and osteopenia impact more than 54 million Americans, resulting in significant
morbidity and mortality. Alterations in bone remodeling are the hallmarks for osteoporosis …