Over the last 15 years, the field of neuroscience has evolved toward recognizing the critical
role of astroglia in shaping neuronal synaptic activity and along with the pre-and …

Dopamine replacement therapy with l-DOPA is the most efficacious symptomatic treatment
for Parkinson's disease, but its utility is limited by a development of motor fluctuations and …

Objective To identify markers of resistance to developing Parkinson disease (PD) among
LRRK2 mutation carriers (LRRK2+), we carried out metabolomic profiling in individuals with …

Abstract Adenosine A 2A receptor (A 2A R) is a G-protein coupled receptor that regulates
several important functions in the central nervous system. Large amount of preclinical data …

It is established that purinergic signaling can shape a wide range of physiological functions,
including neurotransmission and neuromodulation. The purinergic system may play a role in …

Caffeine is one of the most used ergogenic aid for physical exercise and sports. However, its
mechanism of action is still controversial. The adenosinergic hypothesis is promising due to …

This Opinion assesses the biological relevance of the non‐monotonic dose responses
(NMDR) identified in a previous EFSA External Report (Beausoleil et al., 2016) produced …

The therapeutic potential of targeting adenosine A2A receptors (A2ARs) is immense due to
their broad expression in the body and central nervous system. The role of A2ARs in …

Adenosine is a naturally occurring nucleoside and an essential component of the energy
production and utilization systems of the body. Adenosine is formed by the degradation of …

This article addresses the bioactive components in coffee aroma, their metabolism, and the
mechanism of action in lowering the risk of various potential health problems. The main …