Mitochondrial dysfunction in Parkinson's disease: new mechanistic insights and therapeutic perspectives

JS Park, RL Davis, CM Sue - Current neurology and neuroscience reports, 2018 - Springer
Abstract Purpose of Review Parkinson's disease (PD) is a complex neurodegenerative
disorder, the aetiology of which is still largely unknown. Overwhelming evidence indicates …

Perinatal and early-life nutrition, epigenetics, and allergy

N Acevedo, B Alashkar Alhamwe, L Caraballo, M Ding… - Nutrients, 2021 - mdpi.com
Epidemiological studies have shown a dramatic increase in the incidence and the
prevalence of allergic diseases over the last several decades. Environmental triggers …

The role of lipids in Parkinson's disease

H Xicoy, B Wieringa, GJM Martens - Cells, 2019 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disease characterized by a progressive
loss of dopaminergic neurons from the nigrostriatal pathway, formation of Lewy bodies, and …

Alpha-synuclein as a biomarker of Parkinson's disease: good, but not good enough

U Ganguly, S Singh, S Pal, S Prasad… - Frontiers in aging …, 2021 - frontiersin.org
Parkinson's disease (PD) is the second most common neurodegenerative disorder of the
elderly, presenting primarily with symptoms of motor impairment. The disease is diagnosed …

Epigenetic modification of nucleic acids: from basic studies to medical applications

Y Chen, T Hong, S Wang, J Mo, T Tian… - Chemical Society …, 2017 - pubs.rsc.org
The epigenetic modification of nucleic acids represents one of the most significant areas of
study in the field of nucleic acids because it makes gene regulation more complex and …

Fatty acids: an insight into the pathogenesis of neurodegenerative diseases and therapeutic potential

DJ Vesga-Jiménez, C Martin, GE Barreto… - International journal of …, 2022 - mdpi.com
One of the most common lipids in the human body is palmitic acid (PA), a saturated fatty acid
with essential functions in brain cells. PA is used by cells as an energy source, besides …

PINK1 primes Parkin-mediated ubiquitination of PARIS in dopaminergic neuronal survival

Y Lee, DA Stevens, SU Kang, H Jiang, YI Lee, HS Ko… - Cell reports, 2017 - cell.com
Mutations in PTEN-induced putative kinase 1 (PINK1) and parkin cause autosomal-
recessive Parkinson's disease through a common pathway involving mitochondrial quality …

[HTML][HTML] Epigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration

M Neal, JR Richardson - Biochimica et Biophysica Acta (BBA)-Molecular …, 2018 - Elsevier
Epigenetic mechanisms control various functions throughout the body, from cell fate
determination in development to immune responses and inflammation. Neuroinflammation …

The role of NURR1 in metabolic abnormalities of Parkinson's disease

M Al-Nusaif, Y Yang, S Li, C Cheng, W Le - Molecular neurodegeneration, 2022 - Springer
A constant metabolism and energy supply are crucial to all organs, particularly the brain.
Age-dependent neurodegenerative diseases, such as Parkinson's disease (PD), are …

Epigenetics control microglia plasticity

M Cheray, B Joseph - Frontiers in cellular neuroscience, 2018 - frontiersin.org
Microglia, resident immune cells of the central nervous system, fulfill multiple functions in the
brain throughout life. These microglial functions range from participation in innate and …