Mitochondrial dysfunction in Parkinson's disease: new mechanistic insights and therapeutic perspectives
Abstract Purpose of Review Parkinson's disease (PD) is a complex neurodegenerative
disorder, the aetiology of which is still largely unknown. Overwhelming evidence indicates …
disorder, the aetiology of which is still largely unknown. Overwhelming evidence indicates …
Perinatal and early-life nutrition, epigenetics, and allergy
N Acevedo, B Alashkar Alhamwe, L Caraballo, M Ding… - Nutrients, 2021 - mdpi.com
Epidemiological studies have shown a dramatic increase in the incidence and the
prevalence of allergic diseases over the last several decades. Environmental triggers …
prevalence of allergic diseases over the last several decades. Environmental triggers …
The role of lipids in Parkinson's disease
H Xicoy, B Wieringa, GJM Martens - Cells, 2019 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disease characterized by a progressive
loss of dopaminergic neurons from the nigrostriatal pathway, formation of Lewy bodies, and …
loss of dopaminergic neurons from the nigrostriatal pathway, formation of Lewy bodies, and …
Alpha-synuclein as a biomarker of Parkinson's disease: good, but not good enough
Parkinson's disease (PD) is the second most common neurodegenerative disorder of the
elderly, presenting primarily with symptoms of motor impairment. The disease is diagnosed …
elderly, presenting primarily with symptoms of motor impairment. The disease is diagnosed …
Epigenetic modification of nucleic acids: from basic studies to medical applications
The epigenetic modification of nucleic acids represents one of the most significant areas of
study in the field of nucleic acids because it makes gene regulation more complex and …
study in the field of nucleic acids because it makes gene regulation more complex and …
Fatty acids: an insight into the pathogenesis of neurodegenerative diseases and therapeutic potential
One of the most common lipids in the human body is palmitic acid (PA), a saturated fatty acid
with essential functions in brain cells. PA is used by cells as an energy source, besides …
with essential functions in brain cells. PA is used by cells as an energy source, besides …
PINK1 primes Parkin-mediated ubiquitination of PARIS in dopaminergic neuronal survival
Mutations in PTEN-induced putative kinase 1 (PINK1) and parkin cause autosomal-
recessive Parkinson's disease through a common pathway involving mitochondrial quality …
recessive Parkinson's disease through a common pathway involving mitochondrial quality …
[HTML][HTML] Epigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration
M Neal, JR Richardson - Biochimica et Biophysica Acta (BBA)-Molecular …, 2018 - Elsevier
Epigenetic mechanisms control various functions throughout the body, from cell fate
determination in development to immune responses and inflammation. Neuroinflammation …
determination in development to immune responses and inflammation. Neuroinflammation …
The role of NURR1 in metabolic abnormalities of Parkinson's disease
M Al-Nusaif, Y Yang, S Li, C Cheng, W Le - Molecular neurodegeneration, 2022 - Springer
A constant metabolism and energy supply are crucial to all organs, particularly the brain.
Age-dependent neurodegenerative diseases, such as Parkinson's disease (PD), are …
Age-dependent neurodegenerative diseases, such as Parkinson's disease (PD), are …
Epigenetics control microglia plasticity
Microglia, resident immune cells of the central nervous system, fulfill multiple functions in the
brain throughout life. These microglial functions range from participation in innate and …
brain throughout life. These microglial functions range from participation in innate and …