HIV‐1 neutralizing antibodies: understanding nature's pathways

JR Mascola, BF Haynes - Immunological reviews, 2013 - Wiley Online Library
The development of an effective vaccine has been hindered by the enormous diversity of
human immunodeficiency virus‐1 (HIV‐1) and its ability to escape a myriad of host immune …

The HIV-1 envelope glycoproteins: fusogens, antigens, and immunogens

R Wyatt, J Sodroski - Science, 1998 - science.org
The human immunodeficiency virus–type 1 (HIV-1) envelope glycoproteins interact with
receptors on the target cell and mediate virus entry by fusing the viral and cell membranes …

An inhaled ACE2 decoy confers protection against SARS-CoV-2 infection in preclinical models

E Urano, Y Itoh, T Suzuki, T Sasaki… - Science translational …, 2023 - science.org
The Omicron variant continuously evolves under the humoral immune pressure exerted by
vaccination and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …

[HTML][HTML] Core structure of gp41 from the HIV envelope glycoprotein

DC Chan, D Fass, JM Berger, PS Kim - Cell, 1997 - cell.com
The envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1) consists of a
complex of gp120 and gp41. gp120 determines viral tropism by binding to target-cell …

[图书][B] Fields' virology

BN Fields - 2007 - books.google.com
Established for 20 years as the definitive virology reference, the two-volume classic Fields
Virology is in its thoroughly revised, updated Fifth Edition. More than 100 world-renowned …

Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome

RA Koup, JT Safrit, Y Cao, CA Andrews… - Journal of …, 1994 - Am Soc Microbiol
Virologic and immunologic studies were performed on five patients presenting with primary
human immunodeficiency virus type 1 (HIV-1) infection. CD8+ cytotoxic T lymphocyte (CTL) …

[HTML][HTML] Potent prophylactic and therapeutic efficacy of recombinant human ACE2-Fc against SARS-CoV-2 infection in vivo

Z Zhang, E Zeng, L Zhang, W Wang, Y Jin, J Sun… - Cell Discovery, 2021 - nature.com
The current COVID-19 pandemic, caused by SARS-CoV-2, poses a serious public health
threat. Effective therapeutic and prophylactic treatments are urgently needed. Angiotensin …

Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody

DR Burton, J Pyati, R Koduri, SJ Sharp, GB Thornton… - Science, 1994 - science.org
The ability of antibodies to neutralize diverse primary isolates of human immunodeficiency
virus-type 1 in vitro has been questioned, with implications for the likely efficacy of vaccines …

Pathogenesis of human immunodeficiency virus infection

JA Levy - Microbiological reviews, 1993 - Am Soc Microbiol
The lentivirus human immunodeficiency virus (HIV) causes AIDS by interacting with a large
number of different cells in the body and escaping the host immune response against it. HIV …

HIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cells

J Arthos, C Cicala, E Martinelli, K Macleod… - Nature …, 2008 - nature.com
Infection with human immunodeficiency virus 1 (HIV-1) results in the dissemination of virus
to gut-associated lymphoid tissue. Subsequently, HIV-1 mediates massive depletion of gut …