Breast Cancer (BC) is the most commonly diagnosed cancer and second leading cause of
mortality among women. About 1 in 8 US women (about 13%) will develop invasive BC …

Activation of oncogenes and loss of tumour suppressors promote metabolic reprogramming
in cancer, resulting in enhanced nutrient uptake to supply energetic and biosynthetic …

Decades ago, Otto Warburg observed that cancers ferment glucose in the presence of
oxygen, suggesting that defects in mitochondrial respiration may be the underlying cause of …

The current preclinical and clinical findings demonstrate that, in addition to the conventional
clinical and pathological indicators that have a prognostic value in radiation oncology, the …

Purpose: Inhibition of monocarboxylate transporter (MCT) 1–mediated lactate transport may
have cytostatic and/or cytotoxic effects on tumor cells. We report results from the dose …

Instrumentation for positron emission tomography (PET) imaging has experienced
tremendous improvements in performance over the past 60 years since it was first conceived …

The major facilitator superfamily glucose transporters, exemplified by human GLUT1–4,
have been central to the study of solute transport. Using lipidic cubic phase crystallization …

Multimodal positron emission tomography-computed tomography (PET-CT) is used routinely
in the assessment of cancer. PET-CT combines the high sensitivity for tumor detection of …

Glucose is the primary fuel to life on earth. Cellular uptake of glucose is a fundamental
process for metabolism, growth, and homeostasis. Three families of secondary glucose …

Glucose is a major metabolic substrate required for cancer cell survival and growth. It is
mainly imported into cells by facilitated glucose transporters (GLUTs). Here we demonstrate …